eprintid: 3327
rev_number: 7
eprint_status: archive
userid: 69
dir: disk0/00/00/33/27
datestamp: 2016-03-23 13:44:21
lastmod: 2016-04-06 08:32:15
status_changed: 2016-03-23 13:44:21
type: article
metadata_visibility: show
creators_name: Schapiro, Mark B.
creators_name: Pietrini, Pietro
creators_name: Grady, Cheryl L.
creators_name: Ball, M.J.
creators_name: De Carli, Charles
creators_name: Kumar, Anand
creators_name: Kaye, Jeffrey A.
creators_name: Haxby, James V.
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: Reduction in the regional cerebral metabolic rate for glucose (rCMRglc) in the parietal and temporal regions has been shown in Alzheimer's disease (AD). The specificity of these findings for this disease state is uncertain. We repeatedly measured rCMRglc with positron emission tomography and 18F2-fluoro-2-deoxy-D-glucose in the resting state in a 68 year old man with slowly progressive dementia who, during life, was initially diagnosed as having dementia of the Alzheimer type, then Parkinson disease with dementia, but was found to have only Parkinson's disease at necropsy. Metabolic ratios (rCMRglc/mean grey CMRglc) were significantly (p <0 05) reduced in parietal and temporal regions, as well as in the prefrontal and premotor areas. This pattern was similar in regional distribution and magnitude of the defect to that seen in patients with probable AD. These results suggest that reductions of glucose metabolism in association neocortex in AD are not specific to the disease process, but may be related to the dementia state.
date: 1993
date_type: published
publication: Journal of Neurology, Neurosurgery and Psychiatry
volume: 56
number: 8
publisher: BMJ Publishing Group
pagerange: 859-864
id_number: 10.1136/jnnp.56.8.859
refereed: TRUE
issn: 0022-3050
official_url: http://jnnp.bmj.com/content/56/8/859
citation:   Schapiro, Mark B. and Pietrini, Pietro and Grady, Cheryl L. and Ball, M.J. and De Carli, Charles and Kumar, Anand and Kaye, Jeffrey A. and Haxby, James V.  Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease.  Journal of Neurology, Neurosurgery and Psychiatry, 56 (8).  pp. 859-864.  ISSN 0022-3050      (1993)