@article{eprints3328,
         journal = {Dementia},
       publisher = {Karger},
          author = {Pietro Pietrini and Nina P. Azari and Cheryl L. Grady and Judith A. Salerno and A. Gonzales-Aviles and L. L. Heston and Karen D. Pettigrew and Barry Horwitz and James V. Haxby and Mark B. Schapiro},
          volume = {4},
           pages = {94--101},
          number = {2},
           title = {Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation},
            year = {1993},
        abstract = {A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.},
             url = {http://eprints.imtlucca.it/3328/}
}