relation: http://eprints.imtlucca.it/3328/
title: Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation
creator: Pietrini, Pietro
creator: Azari, Nina P.
creator: Grady, Cheryl L.
creator: Salerno, Judith A.
creator: Gonzales-Aviles, A.
creator: Heston, L. L.
creator: Pettigrew, Karen D.
creator: Horwitz, Barry
creator: Haxby, James V.
creator: Schapiro, Mark B.
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.
publisher: Karger
date: 1993
type: Article
type: PeerReviewed
identifier:   Pietrini, Pietro and Azari, Nina P. and Grady, Cheryl L. and Salerno, Judith A. and Gonzales-Aviles, A. and Heston, L. L. and Pettigrew, Karen D. and Horwitz, Barry and Haxby, James V. and Schapiro, Mark B.  Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation.  Dementia, 4 (2).  pp. 94-101.  ISSN 1013-7424      (1993)  
relation: http://www.karger.com/Article/Abstract/107349
relation: 10.1159/000107349