%0 Journal Article
%@ 1013-7424
%A Pietrini, Pietro
%A Azari, Nina P.
%A Grady, Cheryl L.
%A Salerno, Judith A.
%A Gonzales-Aviles, A.
%A Heston, L. L.
%A Pettigrew, Karen D.
%A Horwitz, Barry
%A Haxby, James V.
%A Schapiro, Mark B.
%D 1993
%F eprints:3328
%I Karger
%J Dementia
%N 2
%P 94-101
%T Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation
%U http://eprints.imtlucca.it/3328/
%V 4
%X A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.