<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation"^^ . "A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans."^^ . "1993" . "4" . "2" . . "Karger"^^ . . . "Dementia"^^ . . . "10137424" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Cheryl L."^^ . "Grady"^^ . "Cheryl L. Grady"^^ . . "Judith A."^^ . "Salerno"^^ . "Judith A. Salerno"^^ . . "Karen D."^^ . "Pettigrew"^^ . "Karen D. Pettigrew"^^ . . "L. L."^^ . "Heston"^^ . "L. L. Heston"^^ . . "James V."^^ . "Haxby"^^ . "James V. Haxby"^^ . . "Nina P."^^ . "Azari"^^ . "Nina P. Azari"^^ . . "Mark B."^^ . "Schapiro"^^ . "Mark B. Schapiro"^^ . . "A."^^ . "Gonzales-Aviles"^^ . "A. Gonzales-Aviles"^^ . . "Pietro"^^ . "Pietrini"^^ . "Pietro Pietrini"^^ . . "Barry"^^ . "Horwitz"^^ . "Barry Horwitz"^^ . . . . . "HTML Summary of #3328 \n\nPattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation\n\n" . "text/html" . . . "RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry"@en . .