TY  - JOUR
JF  - Dementia
UR  - http://www.karger.com/Article/Abstract/107349
A1  - Pietrini, Pietro
A1  - Azari, Nina P.
A1  - Grady, Cheryl L.
A1  - Salerno, Judith A.
A1  - Gonzales-Aviles, A.
A1  - Heston, L. L.
A1  - Pettigrew, Karen D.
A1  - Horwitz, Barry
A1  - Haxby, James V.
A1  - Schapiro, Mark B.
Y1  - 1993///
VL  - 4
PB  - Karger
IS  - 2
AV  - none
SN  - 1013-7424
ID  - eprints3328
EP  - 101
SP  - 94
TI  - Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation
N2  - A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.
ER  -