%I Karger
%V 4
%P 94-101
%T Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation
%R 10.1159/000107349
%N 2
%J Dementia
%A Pietro Pietrini
%A Nina P. Azari
%A Cheryl L. Grady
%A Judith A. Salerno
%A A. Gonzales-Aviles
%A L. L. Heston
%A Karen D. Pettigrew
%A Barry Horwitz
%A James V. Haxby
%A Mark B. Schapiro
%X A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.
%L eprints3328
%D 1993