eprintid: 3328
rev_number: 7
eprint_status: archive
userid: 69
dir: disk0/00/00/33/28
datestamp: 2016-03-23 13:47:40
lastmod: 2016-04-05 12:33:57
status_changed: 2016-03-23 13:47:40
type: article
metadata_visibility: show
creators_name: Pietrini, Pietro
creators_name: Azari, Nina P.
creators_name: Grady, Cheryl L.
creators_name: Salerno, Judith A.
creators_name: Gonzales-Aviles, A.
creators_name: Heston, L. L.
creators_name: Pettigrew, Karen D.
creators_name: Horwitz, Barry
creators_name: Haxby, James V.
creators_name: Schapiro, Mark B.
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
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title: Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.
date: 1993
date_type: published
publication: Dementia
volume: 4
number: 2
publisher: Karger
pagerange: 94-101
id_number: 10.1159/000107349
refereed: TRUE
issn: 1013-7424
official_url: http://www.karger.com/Article/Abstract/107349
citation:   Pietrini, Pietro and Azari, Nina P. and Grady, Cheryl L. and Salerno, Judith A. and Gonzales-Aviles, A. and Heston, L. L. and Pettigrew, Karen D. and Horwitz, Barry and Haxby, James V. and Schapiro, Mark B.  Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation.  Dementia, 4 (2).  pp. 94-101.  ISSN 1013-7424      (1993)