relation: http://eprints.imtlucca.it/3330/
title: The monosialoganglioside {GM1} dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats
creator: Freo, Ulderico
creator: Dam, Mauro
creator: Pizzolato, Gilberto
creator: Pietrini, Pietro
creator: Soncrant, Timothy T.
creator: Battistin, Leontino
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: Using the quantitative autoradiographic 14C2-deoxyglucose technique, regional cerebral metabolis rats for glucose (rCMRglc) were measured in awake male Fischer-344 rats at 1,2,3,4 and 6 h after administration of \{GM1\} 30 mg/kg and at 3 h after \{GM1\} 150 or 300 mg/kg. \{GM1\} is a natural compound that is able to prevent neuron degeneration induced by exposure to excitatory amino acids in vitro and by ischemia or neurotoxins in vivo. \{GM1\} 30 mg/kg, a dose very effective in preventing excitatory amino acid-induced neurotoxicity, produced minimal rCMRglc change over a 6 h period. \{GM1\} 150 and 300 mg/kg reduced rCMRglc, in 14 (31%) and in 29 (64%) brain regions, respectively. Maximal metabolic effects occurred in hippocampal areas which possess, in specific subfields, the highest brain concentrations of different excitatory amino acid receptor subtypes. This finding suggests an effect by \{GM1\} on postreceptor mechanisms common to different excitatory amino acids.
publisher: Elsevier
date: 1993
type: Article
type: PeerReviewed
identifier:   Freo, Ulderico and Dam, Mauro and Pizzolato, Gilberto and Pietrini, Pietro and Soncrant, Timothy T. and Battistin, Leontino  The monosialoganglioside {GM1} dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats.  Brain Research Bulletin, 621 (1).  175 - 179.  ISSN 0361-9230      (1993)  
relation: http://www.sciencedirect.com/science/article/pii/000689939390317G
relation: 10.1016/0006-8993(93)90317-G