TY  - JOUR
ID  - eprints3330
EP  -  179
SN  - 0361-9230
N2  - Using the quantitative autoradiographic 14C2-deoxyglucose technique, regional cerebral metabolis rats for glucose (rCMRglc) were measured in awake male Fischer-344 rats at 1,2,3,4 and 6 h after administration of \{GM1\} 30 mg/kg and at 3 h after \{GM1\} 150 or 300 mg/kg. \{GM1\} is a natural compound that is able to prevent neuron degeneration induced by exposure to excitatory amino acids in vitro and by ischemia or neurotoxins in vivo. \{GM1\} 30 mg/kg, a dose very effective in preventing excitatory amino acid-induced neurotoxicity, produced minimal rCMRglc change over a 6 h period. \{GM1\} 150 and 300 mg/kg reduced rCMRglc, in 14 (31%) and in 29 (64%) brain regions, respectively. Maximal metabolic effects occurred in hippocampal areas which possess, in specific subfields, the highest brain concentrations of different excitatory amino acid receptor subtypes. This finding suggests an effect by \{GM1\} on postreceptor mechanisms common to different excitatory amino acids.
AV  - none
TI  - The monosialoganglioside {GM1} dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats
KW  - Monosialoganglioside GM1; Glucose metabolic rate; Cerebral metabolism; Excitatory amino acid; Hippocampus
UR  - http://www.sciencedirect.com/science/article/pii/000689939390317G
VL  - 621
A1  - Freo, Ulderico
A1  - Dam, Mauro
A1  - Pizzolato, Gilberto
A1  - Pietrini, Pietro
A1  - Soncrant, Timothy T.
A1  - Battistin, Leontino
PB  - Elsevier
SP  - 175 
Y1  - 1993///
IS  - 1
JF  - Brain Research Bulletin
ER  -