eprintid: 3330
rev_number: 5
eprint_status: archive
userid: 69
dir: disk0/00/00/33/30
datestamp: 2016-03-23 13:51:06
lastmod: 2016-03-23 13:51:06
status_changed: 2016-03-23 13:51:06
type: article
metadata_visibility: show
creators_name: Freo, Ulderico
creators_name: Dam, Mauro
creators_name: Pizzolato, Gilberto
creators_name: Pietrini, Pietro
creators_name: Soncrant, Timothy T.
creators_name: Battistin, Leontino
creators_id: 
creators_id: 
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
title: The monosialoganglioside {GM1} dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
keywords: Monosialoganglioside GM1; Glucose metabolic rate; Cerebral metabolism; Excitatory amino acid; Hippocampus
abstract: Using the quantitative autoradiographic 14C2-deoxyglucose technique, regional cerebral metabolis rats for glucose (rCMRglc) were measured in awake male Fischer-344 rats at 1,2,3,4 and 6 h after administration of \{GM1\} 30 mg/kg and at 3 h after \{GM1\} 150 or 300 mg/kg. \{GM1\} is a natural compound that is able to prevent neuron degeneration induced by exposure to excitatory amino acids in vitro and by ischemia or neurotoxins in vivo. \{GM1\} 30 mg/kg, a dose very effective in preventing excitatory amino acid-induced neurotoxicity, produced minimal rCMRglc change over a 6 h period. \{GM1\} 150 and 300 mg/kg reduced rCMRglc, in 14 (31%) and in 29 (64%) brain regions, respectively. Maximal metabolic effects occurred in hippocampal areas which possess, in specific subfields, the highest brain concentrations of different excitatory amino acid receptor subtypes. This finding suggests an effect by \{GM1\} on postreceptor mechanisms common to different excitatory amino acids.
date: 1993
date_type: published
publication: Brain Research Bulletin
volume: 621
number: 1
publisher: Elsevier
pagerange: 175 - 179
id_number: 10.1016/0006-8993(93)90317-G
refereed: TRUE
issn: 0361-9230
official_url: http://www.sciencedirect.com/science/article/pii/000689939390317G
citation:   Freo, Ulderico and Dam, Mauro and Pizzolato, Gilberto and Pietrini, Pietro and Soncrant, Timothy T. and Battistin, Leontino  The monosialoganglioside {GM1} dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats.  Brain Research Bulletin, 621 (1).  175 - 179.  ISSN 0361-9230      (1993)