@article{eprints3331,
       publisher = {Springer},
           pages = {53--59},
           title = {The tricyclic antidepressant clomipramine dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats},
         journal = {Psychopharmacology},
            year = {1993},
          author = {Ulderico Freo and Pietro Pietrini and Mario Damiano and Gilberto Pizzolato and Leontino Battistin},
          volume = {113},
          number = {1},
        abstract = {The time course and the relation to dose of regional cerebral metabolic rates for glucose (rCMRglc) were measured in awake male Fischer-344 rats after administration of clomipramine (CMI), a serotonin (5-HT) uptake inhibitor and clinical antidepressant. rCMRglc was determined, using the quantitative autoradiographic 14C2-deoxyglucose technique, in 64 brain regions at 20, 40, 60, 120, and 180 min after administration of CMI 50 mg/kg IP and 120 min after CMI 2 and 10 mg/kg IP. The peak metabolic effect was observed at 120 min after CMI. At that time, CMI 2 and 10 mg/kg IP significantly reduced rCMRglc from control values in 12 (19{$\backslash$}\%) and 14 (22{$\backslash$}\%) brain regions, which correspond to areas with high densities of 5-HT reuptake sites (e.g. visual and limbic areas and raphe nuclei). CMI 50 mg/kg produced widespread rCMRglc reductions in 34 (53{$\backslash$}\%) brain regions, including cortical, hippocampal, raphe and cerebellar areas. The topographic distribution and the relation to time and dose of CMI effects on rCMRglc are different from those of 5-HT1A 8-hydroxy-2(di-N-propylamino) tetralin, 5-HT1B-C (m-chlorophenylpiperazine) and 5-HT3 (quipazine) agonists and resemble those produced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), an agonist of 5-HT2 receptors, suggesting that CMI may prefentially stimulate this 5-HT receptor subtype.},
        keywords = {Clomipramine; Serotonin; Rats; Brain; Metabolism},
             url = {http://eprints.imtlucca.it/3331/}
}