eprintid: 3331
rev_number: 5
eprint_status: archive
userid: 69
dir: disk0/00/00/33/31
datestamp: 2016-03-23 13:53:41
lastmod: 2016-03-23 13:53:41
status_changed: 2016-03-23 13:53:41
type: article
metadata_visibility: show
creators_name: Freo, Ulderico
creators_name: Pietrini, Pietro
creators_name: Damiano, Mario
creators_name: Pizzolato, Gilberto
creators_name: Battistin, Leontino
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
title: The tricyclic antidepressant clomipramine dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
keywords: Clomipramine; Serotonin; Rats; Brain; Metabolism
abstract: The time course and the relation to dose of regional cerebral metabolic rates for glucose (rCMRglc) were measured in awake male Fischer-344 rats after administration of clomipramine (CMI), a serotonin (5-HT) uptake inhibitor and clinical antidepressant. rCMRglc was determined, using the quantitative autoradiographic 14C2-deoxyglucose technique, in 64 brain regions at 20, 40, 60, 120, and 180 min after administration of CMI 50 mg/kg IP and 120 min after CMI 2 and 10 mg/kg IP. The peak metabolic effect was observed at 120 min after CMI. At that time, CMI 2 and 10 mg/kg IP significantly reduced rCMRglc from control values in 12 (19\%) and 14 (22\%) brain regions, which correspond to areas with high densities of 5-HT reuptake sites (e.g. visual and limbic areas and raphe nuclei). CMI 50 mg/kg produced widespread rCMRglc reductions in 34 (53\%) brain regions, including cortical, hippocampal, raphe and cerebellar areas. The topographic distribution and the relation to time and dose of CMI effects on rCMRglc are different from those of 5-HT1A 8-hydroxy-2(di-N-propylamino) tetralin, 5-HT1B-C (m-chlorophenylpiperazine) and 5-HT3 (quipazine) agonists and resemble those produced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), an agonist of 5-HT2 receptors, suggesting that CMI may prefentially stimulate this 5-HT receptor subtype.
date: 1993
date_type: published
publication: Psychopharmacology
volume: 113
number: 1
publisher: Springer
pagerange: 53-59
id_number: 10.1007/BF02244334
refereed: TRUE
issn: 0033-3158
official_url: http://dx.doi.org/10.1007/BF02244334
citation:   Freo, Ulderico and Pietrini, Pietro and Damiano, Mario and Pizzolato, Gilberto and Battistin, Leontino  The tricyclic antidepressant clomipramine dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats.  Psychopharmacology, 113 (1).  pp. 53-59.  ISSN 0033-3158      (1993)