relation: http://eprints.imtlucca.it/3332/
title: Early Detection of Alzheimer's Disease: A Statistical Approach Using Positron Emission Tomographic Data
creator: Azari, Nina P.
creator: Pettigrew, Karen D.
creator: Schapiro, Mark B.
creator: Haxby, James V.
creator: Grady, Cheryl L.
creator: Pietrini, Pietro
creator: Salerno, Judith A.
creator: Heston, L. L.
creator: Rapoport, Stanley I.
creator: Horwitz, Barry
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: Correlational analysis of regional cerebral glucose metabolism (rCMRglc) obtained by high-resolution positron emission tomography (PET) has demonstrated reduced neocortical rCMRglc interactions in mildly/moderately demented patients with probable Alzheimer's disease (AD). Thus, identification of individual differences in patterns of rCMRglc interactions may be important for the early detection of AD, particularly among individuals at greater risk for developing AD (e.g., those with a family history of AD). Recently, a statistical procedure, using multiple regression and discriminant analysis, was developed to assess individual differences in patterns of rCMRglc interdependencies. We applied this new statistical procedure to resting rCMRglc PET data from mildly/moderately demented patients with probable AD and age/sex-matched controls. The aims of the study were to identify a discriminant function that would (a) distinguish patients from controls and (b) identify an AD pattern in an individual at risk for AD with isolated memory impairment whose initial PET scan showed minor abnormalities, but whose second scan showed parietal hypometabolism, coincident with further cognitive decline. Two discriminant functions, reflecting interactions involving regions most involved in reduced correlations in probable AD, correctly classified 87 of the patients and controls, and successfully identified the first scan of the at-risk individual as AD (probability >0.70). The results suggest that this statistical approach may be useful for the early detection of AD.
publisher: Sage
date: 1993
type: Article
type: PeerReviewed
identifier:   Azari, Nina P. and Pettigrew, Karen D. and Schapiro, Mark B. and Haxby, James V. and Grady, Cheryl L. and Pietrini, Pietro and Salerno, Judith A. and Heston, L. L. and Rapoport, Stanley I. and Horwitz, Barry  Early Detection of Alzheimer's Disease: A Statistical Approach Using Positron Emission Tomographic Data.  Journal of Cerebral Blood Flow & Metabolism, 13 (3).  pp. 438-447.  ISSN 0271-678X      (1993)  
relation: http://jcb.sagepub.com/content/13/3/438.abstract
relation: 10.1038/jcbfm.1993.58