%0 Journal Article
%@ 0006-3223
%A Azari, Nina P.
%A Pietrini, Pietro
%A Horwitz, Barry
%A Pettigrew, Karen D.
%A Leonard, H.L.
%A Rapoport, Judith L.
%A Schapiro, Mark B.
%A Swedo, Susan E.
%D 1993
%F eprints:3333
%I Elsevier
%J Biological Psychiatry
%K Obsessive-compulsive disorder; positron emission tomography; discriminant analysis; brain; clomipramine/fluoxetine; metabolism
%N 11
%P 798 - 809
%T Individual differences in cerebral metabolic patterns during pharmacotherapy in obsessive-compulsive disorder: A multiple regression/discriminant analysis of positron emission tomographic data
%U http://eprints.imtlucca.it/3333/
%V 34
%X A multiple regression/discriminant analysis of positron emission tomographic cerebral metabolic (rCMRglc) data in 10 obsessive-compulsive disorder (OCD) patients before and during pharmacotherapy was carried out to see if rCMRglc interdependencies distinguished OCD patients from controls. Before therapy, a discriminant function reflecting parietal, sensorimotor, and midbrain rCMRglc interdependencies correctly classified eight (80) of the 10 patients as OCD; after therapy, six (70) were classified as controls, most of whom were responders. Before therapy, rCMRglc interdependencies involving basal ganglia, thalamus, limbic, and sensory and association cortical regions distinguished 67 of patients who clinically responded to drug (RESP, n = 6) and 75 of patients who did not (NRESP, n = 4) from controls. After therapy, all RESP were classified as controls; classification of NRESP remained unchanged. The results suggest the conjunctive utility of this method to assess individual differences in rCMRglc during pharmacotherapy, and to explore the neurobiology of OCD.