TY  - JOUR
A1  - Azari, Nina P.
A1  - Pietrini, Pietro
A1  - Horwitz, Barry
A1  - Pettigrew, Karen D.
A1  - Leonard, H.L.
A1  - Rapoport, Judith L.
A1  - Schapiro, Mark B.
A1  - Swedo, Susan E.
PB  - Elsevier
SP  - 798 
Y1  - 1993///
IS  - 11
JF  - Biological Psychiatry
VL  - 34
SN  - 0006-3223
N2  - A multiple regression/discriminant analysis of positron emission tomographic cerebral metabolic (rCMRglc) data in 10 obsessive-compulsive disorder (OCD) patients before and during pharmacotherapy was carried out to see if rCMRglc interdependencies distinguished OCD patients from controls. Before therapy, a discriminant function reflecting parietal, sensorimotor, and midbrain rCMRglc interdependencies correctly classified eight (80) of the 10 patients as OCD; after therapy, six (70) were classified as controls, most of whom were responders. Before therapy, rCMRglc interdependencies involving basal ganglia, thalamus, limbic, and sensory and association cortical regions distinguished 67 of patients who clinically responded to drug (RESP, n = 6) and 75 of patients who did not (NRESP, n = 4) from controls. After therapy, all RESP were classified as controls; classification of NRESP remained unchanged. The results suggest the conjunctive utility of this method to assess individual differences in rCMRglc during pharmacotherapy, and to explore the neurobiology of OCD.
TI  - Individual differences in cerebral metabolic patterns during pharmacotherapy in obsessive-compulsive disorder: A multiple regression/discriminant analysis of positron emission tomographic data
AV  - none
KW  - Obsessive-compulsive disorder; positron emission tomography; discriminant analysis; brain; clomipramine/fluoxetine; metabolism
UR  - http://www.sciencedirect.com/science/article/pii/000632239390069P
ID  - eprints3333
EP  -  809
ER  -