TY  - JOUR
UR  - http://www.sciencedirect.com/science/article/pii/000632239390069P
TI  - Individual differences in cerebral metabolic patterns during pharmacotherapy in obsessive-compulsive disorder: A multiple regression/discriminant analysis of positron emission tomographic data
IS  - 11
AV  - none
A1  - Azari, Nina P.
A1  - Pietrini, Pietro
A1  - Horwitz, Barry
A1  - Pettigrew, Karen D.
A1  - Leonard, H.L.
A1  - Rapoport, Judith L.
A1  - Schapiro, Mark B.
A1  - Swedo, Susan E.
SN  - 0006-3223
KW  - Obsessive-compulsive disorder; positron emission tomography; discriminant analysis; brain; clomipramine/fluoxetine; metabolism
ID  - eprints3333
JF  - Biological Psychiatry
EP  -  809
N2  - A multiple regression/discriminant analysis of positron emission tomographic cerebral metabolic (rCMRglc) data in 10 obsessive-compulsive disorder (OCD) patients before and during pharmacotherapy was carried out to see if rCMRglc interdependencies distinguished OCD patients from controls. Before therapy, a discriminant function reflecting parietal, sensorimotor, and midbrain rCMRglc interdependencies correctly classified eight (80) of the 10 patients as OCD; after therapy, six (70) were classified as controls, most of whom were responders. Before therapy, rCMRglc interdependencies involving basal ganglia, thalamus, limbic, and sensory and association cortical regions distinguished 67 of patients who clinically responded to drug (RESP, n = 6) and 75 of patients who did not (NRESP, n = 4) from controls. After therapy, all RESP were classified as controls; classification of NRESP remained unchanged. The results suggest the conjunctive utility of this method to assess individual differences in rCMRglc during pharmacotherapy, and to explore the neurobiology of OCD.
Y1  - 1993///
SP  - 798 
PB  - Elsevier
VL  - 34
ER  -