eprintid: 3333
rev_number: 7
eprint_status: archive
userid: 69
dir: disk0/00/00/33/33
datestamp: 2016-03-23 13:59:36
lastmod: 2016-04-05 12:39:22
status_changed: 2016-03-23 13:59:36
type: article
metadata_visibility: show
creators_name: Azari, Nina P.
creators_name: Pietrini, Pietro
creators_name: Horwitz, Barry
creators_name: Pettigrew, Karen D.
creators_name: Leonard, H.L.
creators_name: Rapoport, Judith L.
creators_name: Schapiro, Mark B.
creators_name: Swedo, Susan E.
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Individual differences in cerebral metabolic patterns during pharmacotherapy in obsessive-compulsive disorder: A multiple regression/discriminant analysis of positron emission tomographic data
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
keywords: Obsessive-compulsive disorder; positron emission tomography; discriminant analysis; brain; clomipramine/fluoxetine; metabolism
abstract: A multiple regression/discriminant analysis of positron emission tomographic cerebral metabolic (rCMRglc) data in 10 obsessive-compulsive disorder (OCD) patients before and during pharmacotherapy was carried out to see if rCMRglc interdependencies distinguished OCD patients from controls. Before therapy, a discriminant function reflecting parietal, sensorimotor, and midbrain rCMRglc interdependencies correctly classified eight (80) of the 10 patients as OCD; after therapy, six (70) were classified as controls, most of whom were responders. Before therapy, rCMRglc interdependencies involving basal ganglia, thalamus, limbic, and sensory and association cortical regions distinguished 67 of patients who clinically responded to drug (RESP, n = 6) and 75 of patients who did not (NRESP, n = 4) from controls. After therapy, all RESP were classified as controls; classification of NRESP remained unchanged. The results suggest the conjunctive utility of this method to assess individual differences in rCMRglc during pharmacotherapy, and to explore the neurobiology of OCD.
date: 1993
date_type: published
publication: Biological Psychiatry
volume: 34
number: 11
publisher: Elsevier
pagerange: 798 - 809
id_number: 10.1016/0006-3223(93)90069-P
refereed: TRUE
issn: 0006-3223
official_url: http://www.sciencedirect.com/science/article/pii/000632239390069P
citation:   Azari, Nina P. and Pietrini, Pietro and Horwitz, Barry and Pettigrew, Karen D. and Leonard, H.L. and Rapoport, Judith L. and Schapiro, Mark B. and Swedo, Susan E.  Individual differences in cerebral metabolic patterns during pharmacotherapy in obsessive-compulsive disorder: A multiple regression/discriminant analysis of positron emission tomographic data.  Biological Psychiatry, 34 (11).  798 - 809.  ISSN 0006-3223      (1993)