@article{eprints3334,
          volume = {5},
          number = {2},
           title = {Detection of an alzheimer disease pattern of cerebral metabolism in down syndrome},
          author = {Nina P. Azari and Karen D. Pettigrew and Pietro Pietrini and Barry Horwitz and Mark B. Schapiro},
            year = {1994},
         journal = {Dementia and Geriatric Cognitive Disorders},
           pages = {69--78},
       publisher = {Karger},
        abstract = {Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer?s disease (AD). A multivariate analysis of rCMRglc data assesses individual differences. We recently identified discriminant functions, reflecting frontal- parietal rCMRglc interdependencies, that separated AD from control subjects. To test if the functions would identify an AD rCMRglc pattern in older Down syndrome (DS) adults with (DS DAT+) or without (DS DAT-) dementia, we applied the functions to longitudinal rCMRglc data in: young DS (n = 15), DS DAT - (n = 10), DS DAT + (n = 4), and young controls (n = 15). All DS DAT+ and some of the later DS DAT- scans were classified as AD. The results provide additional validation of the functions and suggest their utility for the early detection of AD.},
             url = {http://eprints.imtlucca.it/3334/}
}