<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Detection of an alzheimer disease pattern of cerebral metabolism in down syndrome"^^ . "Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer’s disease (AD). A multivariate analysis of rCMRglc data assesses individual differences. We recently identified discriminant functions, reflecting frontal- parietal rCMRglc interdependencies, that separated AD from control subjects. To test if the functions would identify an AD rCMRglc pattern in older Down syndrome (DS) adults with (DS DAT+) or without (DS DAT-) dementia, we applied the functions to longitudinal rCMRglc data in: young DS (n = 15), DS DAT - (n = 10), DS DAT + (n = 4), and young controls (n = 15). All DS DAT+ and some of the later DS DAT- scans were classified as AD. The results provide additional validation of the functions and suggest their utility for the early detection of AD."^^ . "1994" . "5" . "2" . . "Karger"^^ . . . "Dementia and Geriatric Cognitive Disorders"^^ . . . "14208008" . . . . . . . . . . . . . . . . . . . "Karen D."^^ . "Pettigrew"^^ . "Karen D. Pettigrew"^^ . . "Pietro"^^ . "Pietrini"^^ . "Pietro Pietrini"^^ . . "Mark B."^^ . "Schapiro"^^ . "Mark B. Schapiro"^^ . . "Nina P."^^ . "Azari"^^ . "Nina P. Azari"^^ . . "Barry"^^ . "Horwitz"^^ . "Barry Horwitz"^^ . . . . . "HTML Summary of #3334 \n\nDetection of an alzheimer disease pattern of cerebral metabolism in down syndrome\n\n" . "text/html" . . . "RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry"@en . .