TY  - JOUR
Y1  - 1994///
SP  - 69
A1  - Azari, Nina P.
A1  - Pettigrew, Karen D.
A1  - Pietrini, Pietro
A1  - Horwitz, Barry
A1  - Schapiro, Mark B.
SN  - 1420-8008
PB  - Karger
VL  - 5
EP  - 78
UR  - http://www.karger.com/Article/Abstract/106700#
IS  - 2
JF  - Dementia and Geriatric Cognitive Disorders
N2  - Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer?s disease (AD). A multivariate analysis of rCMRglc data assesses individual differences. We recently identified discriminant functions, reflecting frontal- parietal rCMRglc interdependencies, that separated AD from control subjects. To test if the functions would identify an AD rCMRglc pattern in older Down syndrome (DS) adults with (DS DAT+) or without (DS DAT-) dementia, we applied the functions to longitudinal rCMRglc data in: young DS (n = 15), DS DAT - (n = 10), DS DAT + (n = 4), and young controls (n = 15). All DS DAT+ and some of the later DS DAT- scans were classified as AD. The results provide additional validation of the functions and suggest their utility for the early detection of AD.
AV  - none
ID  - eprints3334
TI  - Detection of an alzheimer disease pattern of cerebral metabolism in down syndrome
ER  -