%P 69-78
%A Nina P. Azari
%A Karen D. Pettigrew
%A Pietro Pietrini
%A Barry Horwitz
%A Mark B. Schapiro
%J Dementia and Geriatric Cognitive Disorders
%X Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer’s disease (AD). A multivariate analysis of rCMRglc data assesses individual differences. We recently identified discriminant functions, reflecting frontal- parietal rCMRglc interdependencies, that separated AD from control subjects. To test if the functions would identify an AD rCMRglc pattern in older Down syndrome (DS) adults with (DS DAT+) or without (DS DAT-) dementia, we applied the functions to longitudinal rCMRglc data in: young DS (n = 15), DS DAT - (n = 10), DS DAT + (n = 4), and young controls (n = 15). All DS DAT+ and some of the later DS DAT- scans were classified as AD. The results provide additional validation of the functions and suggest their utility for the early detection of AD.
%L eprints3334
%T Detection of an alzheimer disease pattern of cerebral metabolism in down syndrome
%R 10.1159/000106700
%N 2
%V 5
%I Karger
%D 1994