eprintid: 3334 rev_number: 8 eprint_status: archive userid: 69 dir: disk0/00/00/33/34 datestamp: 2016-03-23 14:01:00 lastmod: 2016-04-05 12:42:28 status_changed: 2016-03-23 14:01:00 type: article metadata_visibility: show creators_name: Azari, Nina P. creators_name: Pettigrew, Karen D. creators_name: Pietrini, Pietro creators_name: Horwitz, Barry creators_name: Schapiro, Mark B. creators_id: creators_id: creators_id: pietro.pietrini@imtlucca.it creators_id: creators_id: title: Detection of an alzheimer disease pattern of cerebral metabolism in down syndrome ispublished: pub subjects: RC0321 divisions: CSA full_text_status: none abstract: Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer’s disease (AD). A multivariate analysis of rCMRglc data assesses individual differences. We recently identified discriminant functions, reflecting frontal- parietal rCMRglc interdependencies, that separated AD from control subjects. To test if the functions would identify an AD rCMRglc pattern in older Down syndrome (DS) adults with (DS DAT+) or without (DS DAT-) dementia, we applied the functions to longitudinal rCMRglc data in: young DS (n = 15), DS DAT - (n = 10), DS DAT + (n = 4), and young controls (n = 15). All DS DAT+ and some of the later DS DAT- scans were classified as AD. The results provide additional validation of the functions and suggest their utility for the early detection of AD. date: 1994 date_type: published publication: Dementia and Geriatric Cognitive Disorders volume: 5 number: 2 publisher: Karger pagerange: 69-78 id_number: 10.1159/000106700 refereed: TRUE issn: 1420-8008 official_url: http://www.karger.com/Article/Abstract/106700# citation: Azari, Nina P. and Pettigrew, Karen D. and Pietrini, Pietro and Horwitz, Barry and Schapiro, Mark B. Detection of an alzheimer disease pattern of cerebral metabolism in down syndrome. Dementia and Geriatric Cognitive Disorders, 5 (2). pp. 69-78. ISSN 1420-8008 (1994)