@article{eprints3340,
           pages = {241--243},
          volume = {86-87},
       publisher = {Lega Italiana contro l'Epilessia},
           title = {MRI-demonstrated atrophy and sclerosis of mesiotemporal structures in children: Good correlation with PET and neuropsychological data and lack of correlation with interictal EEG = Sclerosi ed atrofia delle strutture mesiotemporali dimostrate con RMN nel bambino : buona correlazione con i dati PET e neuropsicologici e mancanza di correlazione con l'EEG di superficie intercritico},
            year = {1994},
          author = {R. Guerrini and Mario Guazzelli and P. Salvadori and P.A. Salvadori and P. Pisani and R. Guzzardi and P. Brovedani and C. Casalini and O. Sorace and S. Marchetti and Pietro Pietrini and A. Bertolino and D. Brizzolara and R. Canapicchi},
         journal = {Bollettino - Lega Italiana contro l'Epilessia},
             url = {http://eprints.imtlucca.it/3340/},
        abstract = {Of 100 consecutive patients who underwent cerebral magnetic resonance imaging (MRI) because of epileptic seizures or prolonged febrile conculsions as presenting symptom, 11 showed hippocampal atrophy and sclerosis, with or without amygdalar involvement. Ten of them had prolonged febrile convulsions (PFC) ({\ensuremath{>}}30 min) in infancy and 10 had epilepsy, characterized in 7 by temporal lobe complex partial seizures, well controlled in 5. In only one patient, interictal EEG abnormalities were focal and homolateral to the lesion; one had also generalized abnormalities, 7 had bilateral abnormalities and 2 had discharges contralateral to the lesion. Memory function assessment in 8 patients showed in 5 material specific impairment, not found in controls or in children with frontal lobe seizures and temporal lobe seizures without demonstrable lesions. Five of the 8 patients studied neuropsychologically underwent proton emission tomography (PET) with 18-FDG to evaluate regional cerebral glucose metabolism (rCMRglc). All showed asymmetric rCMRglc with hypometabolism on the lesion side with lowest values in the mesial temporal region, consistent with neuropsychological data and with ictal EEGs recorded in 2 patients. Structural mesiotemporal abnormalities observed at MRI in children can be correlated with a specific memory dysfunction and with interictal hypometabolism, even when seizures are infrequent. Surface interictal EEG is not reliable in lateralizing the epileptogenic area or lesion.}
}