relation: http://eprints.imtlucca.it/3341/
title: Cerebral Metabolic Responses to Clomipramine Are Greatly Reduced Following Pretreatment with the Specific Serotonin Neurotoxin Para-Chloroamphetamine (PCA)
creator: Freo, Ulderico
creator: Pietrini, Pietro
creator: Pizzolato, Gilberto
creator: Merico, Antonio
creator: Ruggero, Susanna
creator: Dam, Mauro
creator: Battistin, Leontino
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: To determine if reported reductions of regional cerebral metabolic rates for glucose (rCMRglc) induced by the tryciclic antidepressant clomipramine (CMI) (10 mg/kg) are due to a presynaptic action on serotonin (5-HT) terminals, 3-month-old Fischer-344 rats were given parachloroamphetamine (PCA), a serotonin neurotoxin. rCMRglc was measured 3 weeks later in 55 brain regions after the administration of saline or CMI using the quantitative autoradiographic [14C]2-deoxyglucose procedure. PCA alone increased rCMRglc in the visual cortex. CMI alone reduced rCMRglc in 18 (33%) of the studied regions, including telencephalic, diencephalic, limbic, and brain stem areas. In PCA-lesioned rats, metabolic responses to CMI (10 mg/kg) were greatly reduced, and significant rCMRglc decreases were observed only in 4 (7%) of the brain areas, including the hippocampus and raphe nuclei. Abolition by PCA of the metabolic responses to CMI confirms that CMI, at the dose studied, reduces rCMRglc via a presynaptic mechanism, likely the 5-HT reuptake sites.
publisher: Nature Publishing Group
date: 1995
type: Article
type: PeerReviewed
identifier:   Freo, Ulderico and Pietrini, Pietro and Pizzolato, Gilberto and Merico, Antonio and Ruggero, Susanna and Dam, Mauro and Battistin, Leontino  Cerebral Metabolic Responses to Clomipramine Are Greatly Reduced Following Pretreatment with the Specific Serotonin Neurotoxin Para-Chloroamphetamine (PCA).  Neuropsychopharmacology (13).  pp. 2015-222.  ISSN 0893-133X      (1995)  
relation: http://dx.doi.org/10.1016/0893-133X(95)00053-G
relation: 10.1016/0893-133X(95)00053-G