<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Cerebral Metabolic Responses to Clomipramine Are Greatly Reduced Following Pretreatment with the Specific Serotonin Neurotoxin Para-Chloroamphetamine (PCA)"^^ . "To determine if reported reductions of regional cerebral metabolic rates for glucose (rCMRglc) induced by the tryciclic antidepressant clomipramine (CMI) (10 mg/kg) are due to a presynaptic action on serotonin (5-HT) terminals, 3-month-old Fischer-344 rats were given parachloroamphetamine (PCA), a serotonin neurotoxin. rCMRglc was measured 3 weeks later in 55 brain regions after the administration of saline or CMI using the quantitative autoradiographic [14C]2-deoxyglucose procedure. PCA alone increased rCMRglc in the visual cortex. CMI alone reduced rCMRglc in 18 (33%) of the studied regions, including telencephalic, diencephalic, limbic, and brain stem areas. In PCA-lesioned rats, metabolic responses to CMI (10 mg/kg) were greatly reduced, and significant rCMRglc decreases were observed only in 4 (7%) of the brain areas, including the hippocampus and raphe nuclei. Abolition by PCA of the metabolic responses to CMI confirms that CMI, at the dose studied, reduces rCMRglc via a presynaptic mechanism, likely the 5-HT reuptake sites."^^ . "1995" . "13" . . "Nature Publishing Group"^^ . . . "Neuropsychopharmacology"^^ . . . "0893133X" . . . . . . . . . . . . . . . . . . . . . . . . . "Mauro"^^ . "Dam"^^ . "Mauro Dam"^^ . . "Susanna"^^ . "Ruggero"^^ . "Susanna Ruggero"^^ . . "Leontino"^^ . "Battistin"^^ . "Leontino Battistin"^^ . . "Antonio"^^ . "Merico"^^ . "Antonio Merico"^^ . . "Pietro"^^ . "Pietrini"^^ . "Pietro Pietrini"^^ . . "Ulderico"^^ . "Freo"^^ . "Ulderico Freo"^^ . . "Gilberto"^^ . "Pizzolato"^^ . "Gilberto Pizzolato"^^ . . . . . "HTML Summary of #3341 \n\nCerebral Metabolic Responses to Clomipramine Are Greatly Reduced Following Pretreatment with the Specific Serotonin Neurotoxin Para-Chloroamphetamine (PCA)\n\n" . "text/html" . . . "RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry"@en . .