eprintid: 3341
rev_number: 8
eprint_status: archive
userid: 69
dir: disk0/00/00/33/41
datestamp: 2016-04-04 08:23:21
lastmod: 2016-04-04 11:54:16
status_changed: 2016-04-04 08:23:21
type: article
metadata_visibility: show
creators_name: Freo, Ulderico
creators_name: Pietrini, Pietro
creators_name: Pizzolato, Gilberto
creators_name: Merico, Antonio
creators_name: Ruggero, Susanna
creators_name: Dam, Mauro
creators_name: Battistin, Leontino
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Cerebral Metabolic Responses to Clomipramine Are Greatly Reduced Following Pretreatment with the Specific Serotonin Neurotoxin Para-Chloroamphetamine (PCA)
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
note: Fulltext available on publisher's website
abstract: To determine if reported reductions of regional cerebral metabolic rates for glucose (rCMRglc) induced by the tryciclic antidepressant clomipramine (CMI) (10 mg/kg) are due to a presynaptic action on serotonin (5-HT) terminals, 3-month-old Fischer-344 rats were given parachloroamphetamine (PCA), a serotonin neurotoxin. rCMRglc was measured 3 weeks later in 55 brain regions after the administration of saline or CMI using the quantitative autoradiographic [14C]2-deoxyglucose procedure. PCA alone increased rCMRglc in the visual cortex. CMI alone reduced rCMRglc in 18 (33%) of the studied regions, including telencephalic, diencephalic, limbic, and brain stem areas. In PCA-lesioned rats, metabolic responses to CMI (10 mg/kg) were greatly reduced, and significant rCMRglc decreases were observed only in 4 (7%) of the brain areas, including the hippocampus and raphe nuclei. Abolition by PCA of the metabolic responses to CMI confirms that CMI, at the dose studied, reduces rCMRglc via a presynaptic mechanism, likely the 5-HT reuptake sites.
date: 1995
date_type: published
publication: Neuropsychopharmacology
number: 13
publisher: Nature Publishing Group
pagerange: 2015-222
id_number: 10.1016/0893-133X(95)00053-G
refereed: TRUE
issn: 0893-133X
official_url: http://dx.doi.org/10.1016/0893-133X(95)00053-G
citation:   Freo, Ulderico and Pietrini, Pietro and Pizzolato, Gilberto and Merico, Antonio and Ruggero, Susanna and Dam, Mauro and Battistin, Leontino  Cerebral Metabolic Responses to Clomipramine Are Greatly Reduced Following Pretreatment with the Specific Serotonin Neurotoxin Para-Chloroamphetamine (PCA).  Neuropsychopharmacology (13).  pp. 2015-222.  ISSN 0893-133X      (1995)