TY  - JOUR
IS  - 7
UR  - http://www.sciencedirect.com/science/article/pii/000632239400326X
KW  - Glucose brain metabolism; delusion; dementia; frontal lobe; paralimbic system; limbic system
AV  - none
TI  - Abnormal brain glucose metabolism in the delusional misidentification syndromes: A positron emission tomography study in Alzheimer disease
ID  - eprints3347
SP  - 438 
A1  - Mentis, Marc J.
A1  - Weinstein, Edward A.
A1  - Horwitz, Barry
A1  - McIntosh, Andrew R.
A1  - Pietrini, Pietro
A1  - Alexander, Gene E.
A1  - Furey, Maura L.
A1  - Murphy, Declan G.
EP  -  449
VL  - 38
PB  - Elsevier
N2  - Brain lesions have been reported with increasing frequency in the delusional misidentification syndromes (DMS). This is the first controlled study to describe {DMS} regional cerebral metabolic rates of glucose (rCMRglc). We compared rCMRglc (using positron emission tomography) and neuropsychological data in 9 patients with {DMS} and Alzheimer dementia (AD), 15 {AD} patients without DMS, and 17 healthy controls. The {DMS} group differed from the {AD} group without {DMS} in having significant hypometabolism in paralimbic (orbitofrontal and cingulate areas bilaterally) and left medial temporal areas, and significant bilateral normalized hypermetabolism in sensory association cortices (superior temporal and inferior parietal) without right left asymmetry. Compared to healthy controls, both {AD} groups had significant dorsolateral frontal hypometabolism bilaterally. No specific {DMS} neuropsychological profile was identified. Dysfunctional connections among multimodal association areas, paralimbic structures, and dorsolateral frontal cortex are proposed as the predisposing neural deficit underlying DMS, causing cognitive-perceptual-affective dissonance, which under specific conditions results in ?positive? delusion formation.
JF  - Biological Psychiatry
Y1  - 1995///
SN  - 0006-3223
ER  -