eprintid: 3347
rev_number: 7
eprint_status: archive
userid: 69
dir: disk0/00/00/33/47
datestamp: 2016-04-04 08:35:04
lastmod: 2016-04-06 09:09:45
status_changed: 2016-04-04 08:35:04
type: article
metadata_visibility: show
creators_name: Mentis, Marc J.
creators_name: Weinstein, Edward A.
creators_name: Horwitz, Barry
creators_name: McIntosh, Andrew R.
creators_name: Pietrini, Pietro
creators_name: Alexander, Gene E.
creators_name: Furey, Maura L.
creators_name: Murphy, Declan G.
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
title: Abnormal brain glucose metabolism in the delusional misidentification syndromes: A positron emission tomography study in Alzheimer disease
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
keywords: Glucose brain metabolism; delusion; dementia; frontal lobe; paralimbic system; limbic system
abstract: Brain lesions have been reported with increasing frequency in the delusional misidentification syndromes (DMS). This is the first controlled study to describe {DMS} regional cerebral metabolic rates of glucose (rCMRglc). We compared rCMRglc (using positron emission tomography) and neuropsychological data in 9 patients with {DMS} and Alzheimer dementia (AD), 15 {AD} patients without DMS, and 17 healthy controls. The {DMS} group differed from the {AD} group without {DMS} in having significant hypometabolism in paralimbic (orbitofrontal and cingulate areas bilaterally) and left medial temporal areas, and significant bilateral normalized hypermetabolism in sensory association cortices (superior temporal and inferior parietal) without right left asymmetry. Compared to healthy controls, both {AD} groups had significant dorsolateral frontal hypometabolism bilaterally. No specific {DMS} neuropsychological profile was identified. Dysfunctional connections among multimodal association areas, paralimbic structures, and dorsolateral frontal cortex are proposed as the predisposing neural deficit underlying DMS, causing cognitive-perceptual-affective dissonance, which under specific conditions results in “positive” delusion formation.
date: 1995
date_type: published
publication: Biological Psychiatry
volume: 38
number: 7
publisher: Elsevier
pagerange: 438 - 449
id_number: 10.1016/0006-3223(94)00326-X
refereed: TRUE
issn: 0006-3223
official_url: http://www.sciencedirect.com/science/article/pii/000632239400326X
citation:   Mentis, Marc J. and Weinstein, Edward A. and Horwitz, Barry and McIntosh, Andrew R. and Pietrini, Pietro and Alexander, Gene E. and Furey, Maura L. and Murphy, Declan G.  Abnormal brain glucose metabolism in the delusional misidentification syndromes: A positron emission tomography study in Alzheimer disease.  Biological Psychiatry, 38 (7).  438 - 449.  ISSN 0006-3223      (1995)