eprintid: 3406
rev_number: 5
eprint_status: archive
userid: 6
dir: disk0/00/00/34/06
datestamp: 2016-04-12 08:23:27
lastmod: 2016-04-12 08:23:27
status_changed: 2016-04-12 08:23:27
type: article
metadata_visibility: show
creators_name: Zalla, Tiziana
creators_name: Koechlin, Etienne
creators_name: Pietrini, Pietro
creators_name: Basso, Gianpaolo
creators_name: Aquino, Patrick
creators_name: Sirigu, Angela
creators_name: Grafman, Jordan
creators_id: 
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Differential amygdala responses to winning and losing: a functional magnetic resonance imaging study in humans
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: The amygdala has been shown to respond to many distinct types of affective stimuli, including reward and punishment feedback in animals. In humans, winning and losing situations can be considered as reward and punishment experiences, respectively. In this study, we used functional magnetic resonance imaging (fMRI) to measure regional brain activity when human subjects were given feedback on their performance during a simple response time task in a fictitious competitive tournament. Lexical stimuli were used to convey positive ‘win’ or negative ‘lose’ feedback. The frequency of positive and negative trials was parametrically varied by the experimenters independently from the subjects' actual performance and unbeknownst to them. The results showed that the parametric increase of winning was associated with left amygdala activation whereas the parametric increase of losing was associated with right amygdala activation. These findings provide functional evidence that the human amygdala differentially responds to changes in magnitude of positive or negative reinforcement conveyed by lexical stimuli.
date: 2001
publication: European Journal of Neuroscience
volume: 12
number: 5
publisher: Wiley
pagerange: 1764-1770
id_number: doi:10.1046/j.1460-9568.2000.00064.x
refereed: TRUE
issn: 0953-816X
official_url: http://doi.org/10.1046/j.1460-9568.2000.00064.x
citation:   Zalla, Tiziana and Koechlin, Etienne and Pietrini, Pietro and Basso, Gianpaolo and Aquino, Patrick and Sirigu, Angela and Grafman, Jordan  Differential amygdala responses to winning and losing: a functional magnetic resonance imaging study in humans.  European Journal of Neuroscience, 12 (5).  pp. 1764-1770.  ISSN 0953-816X      (2001)