eprintid: 3408
rev_number: 5
eprint_status: archive
userid: 6
dir: disk0/00/00/34/08
datestamp: 2016-04-12 08:32:42
lastmod: 2016-04-12 08:32:42
status_changed: 2016-04-12 08:32:42
type: article
metadata_visibility: show
creators_name: Furey, Maura L.
creators_name: Pietrini, Pietro
creators_name: Haxby, James V.
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
title: Cholinergic enhancement and increased selectivity of perceptual processing during working memory
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: Using functional magnetic resonance imaging, we investigated the mechanism by which cholinergic enhancement improves working memory. We studied the effect of the cholinesterase inhibitor physostigmine on subcomponents of this complex function. Cholinergic enhancement increased the selectivity of neural responses in extrastriate cortices during visual working memory, particularly during encoding. It also increased the participation of ventral extrastriate cortex during memory maintenance and decreased the participation of anterior prefrontal cortex. These results indicate that cholinergic enhancement improves memory performance by augmenting the selectivity of perceptual processing during encoding, thereby simplifying processing demands during memory maintenance and reducing the need for prefrontal participation.
date: 2000
publication: Science
volume: 290
number: 5500
publisher: American Association for the Advancement of Science
pagerange: 2315-2319
id_number: doi:10.1126/science.290.5500.2315
refereed: TRUE
issn: 0036-8075
official_url: http://doi.org/10.1126/science.290.5500.2315
citation:   Furey, Maura L. and Pietrini, Pietro and Haxby, James V.  Cholinergic enhancement and increased selectivity of perceptual processing during working memory.  Science, 290 (5500).  pp. 2315-2319.  ISSN 0036-8075      (2000)