eprintid: 3409
rev_number: 5
eprint_status: archive
userid: 6
dir: disk0/00/00/34/09
datestamp: 2016-04-12 08:42:32
lastmod: 2016-04-12 08:42:32
status_changed: 2016-04-12 08:42:32
type: article
metadata_visibility: show
creators_name: Koechlin, Etienne
creators_name: Corrado, Gregory
creators_name: Pietrini, Pietro
creators_name: Grafman, Jordan
creators_id: 
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
title: Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
keywords: striatum; task switching; anticipation
abstract: The anterior prefrontal cortex is known to subserve higher cognitive functions such as task management and planning. Less is known, however, about the functional specialization of this cortical region in humans. Using functional MRI, we report a double dissociation: the medial anterior prefrontal cortex, in association with the ventral striatum, was engaged preferentially when subjects executed tasks in sequences that were expected, whereas the polar prefrontal cortex, in association with the dorsolateral striatum, was involved preferentially when subjects performed tasks in sequences that were contingent on unpredictable events. These results parallel the functional segregation previously described between the medial and lateral premotor cortex underlying planned and contingent motor control and extend this division to the anterior prefrontal cortex, when task management and planning are required. Thus, our findings support the assumption that common frontal organizational principles underlie motor and higher executive functions in humans.
date: 2000
publication: Proceedings of the National Academy of Sciences
volume: 97
number: 13
pagerange: 7651-7656
id_number: doi:10.1073/pnas.130177397
refereed: TRUE
issn: 1091-6490
official_url: http://doi.org/10.1073/pnas.130177397
citation:   Koechlin, Etienne and Corrado, Gregory and Pietrini, Pietro and Grafman, Jordan  Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning.  Proceedings of the National Academy of Sciences, 97 (13).  pp. 7651-7656.  ISSN 1091-6490      (2000)