eprintid: 3410
rev_number: 5
eprint_status: archive
userid: 6
dir: disk0/00/00/34/10
datestamp: 2016-04-12 08:48:15
lastmod: 2016-04-12 08:48:15
status_changed: 2016-04-12 08:48:15
type: article
metadata_visibility: show
creators_name: Pietrini, Pietro
creators_name: Guazzelli, Mario
creators_name: Basso, Gianpaolo
creators_name: Jaffe, Karen
creators_name: Grafman, Jordan
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: OBJECTIVE: Neurodegenerative or traumatic lesions of the frontal lobes often lead to abnormally aggressive behavior. The authors hypothesized that the imaginal evoking of scenarios involving aggressive behavior would be associated with a modulation of the functional activity in the human frontal cortex. METHOD: Regional cerebral blood flow (rCBF) determinations by positron emission tomography and psychophysiological measures of emotional responsivity were obtained in a group of 15 young healthy volunteers with good visual imagery abilities and no history of abnormal behavior while they imagined the same scenario with four variations involving emotionally neutral behavior and aggressive behavior. RESULTS: Compared to the imagined neutral scenario, the imagined scenarios involving aggressive behavior were associated with significant emotional reactivity and rCBF reductions in the ventromedial prefrontal cortex, suggesting that a functional deactivation of this cortical area occurs when individuals respond to the eliciting of imagined aggressive behavior. CONCLUSIONS: These results in healthy subjects further expand previous findings from animal and human studies by providing an in vivo functional demonstration of the involvement of the orbitofrontal cortex in the expression of aggressive behavior. They are also consistent with the hypothesis that a functional alteration of this cortical region may be present in individuals with pathological aggressive behavior.
date: 2000
publication: American Journal of Psychiatry
volume: 157
number: 11
publisher: American Psychiatric publishing
pagerange: 1772-1781
id_number: doi:10.1176/appi.ajp.157.11.1772
refereed: TRUE
issn: 0002-953X
official_url: http://doi.org/10.1176/appi.ajp.157.11.1772
citation:   Pietrini, Pietro and Guazzelli, Mario and Basso, Gianpaolo and Jaffe, Karen and Grafman, Jordan  Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects.  American Journal of Psychiatry, 157 (11).  pp. 1772-1781.  ISSN 0002-953X      (2000)