eprintid: 3415
rev_number: 7
eprint_status: archive
userid: 69
dir: disk0/00/00/34/15
datestamp: 2016-04-12 08:59:07
lastmod: 2016-04-12 08:59:07
status_changed: 2016-04-12 08:59:07
type: article
metadata_visibility: show
creators_name: Alexander, Gene E.
creators_name: Furey, Maura L.
creators_name: Grady, Cheryl L.
creators_name: Pietrini, Pietro
creators_name: Brady, Daniel R.
creators_name: Mentis, Marc J.
creators_name: Schapiro, Mark B.
creators_id: 
creators_id: 
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
title: Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: OBJECTIVE: Clinical heterogeneity in Alzheimer's disease has been widely observed. One factor that may influence the expression of dementia in Alzheimer's disease is premorbid intellectual ability. It has been hypothesized that premorbid ability, as measured by educational experience, reflects a cognitive reserve that can affect the clinical expression of Alzheimer's disease. The authors investigated the relation between estimates of premorbid intellectual function and cerebral glucose metabolism in patients with Alzheimer's disease to test the effect of differing levels of premorbid ability on neurophysiological dysfunction. METHOD: In a resting state with eyes closed and ears occluded, 46 patients with Alzheimer's disease were evaluated with positron emission tomography and [18F]-2-fluoro-2-deoxy- D-glucose to determine cerebral metabolism. Premorbid intellectual ability was assessed by a demographics-based IQ estimate and performance on a measure of word-reading ability. RESULTS: After the authors controlled for demographic characteristics and dementia severity, both estimates of premorbid intellectual ability were inversely correlated with cerebral metabolism in the prefrontal, pre- motor, and left superior parietal association regions. In addition, the performance-based estimate (i.e., reading ability) was inversely correlated with metabolism in the anterior cingulate, paracentral, right orbitofrontal, and left thalamic regions, after demographic and clinical variables were controlled for. CONCLUSIONS: The results suggest that higher levels of premorbid ability are associated with greater pathophysiological effects of Alzheimer's disease among patients of similar dementia severity levels. These findings provide support for a cognitive reserve that can alter the clinical expression of dementia and influence the neurophysiological heterogeneity observed in Alzheimer's disease.
date: 1997
date_type: published
publication: American Journal of Psychiatry
volume: 154
number: 2
publisher: American Psychiatric publishing
pagerange: 165-172
id_number: 10.1176/ajp.154.2.165
refereed: TRUE
issn: 0002-953X
official_url: http://dx.doi.org/10.1176/ajp.154.2.165
citation:   Alexander, Gene E. and Furey, Maura L. and Grady, Cheryl L. and Pietrini, Pietro and Brady, Daniel R. and Mentis, Marc J. and Schapiro, Mark B.  Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis.  American Journal of Psychiatry, 154 (2).  pp. 165-172.  ISSN 0002-953X      (1997)