eprintid: 3418
rev_number: 5
eprint_status: archive
userid: 6
dir: disk0/00/00/34/18
datestamp: 2016-04-12 09:08:26
lastmod: 2016-04-12 09:08:26
status_changed: 2016-04-12 09:08:26
type: article
metadata_visibility: show
creators_name: Pietrini, Pietro
creators_name: Alexander, Gene E.
creators_name: Furey, Maura L.
creators_name: Hampel, Harald
creators_name: Guazzelli, Mario
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: The neurometabolic landscape of cognitive decline: in vivo studies with positron emission tomography in Alzheimer’s disease
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
keywords: Brain metabolism; Cognition; Dementia; Early diagnosis; Synaptic dysfunction; Human
abstract: Alzheimer’s disease, the most common form of dementia in the elderly, is characterized by the progressive, global and irreversible deterioration of cognitive abilities. The development of positron emission tomography (PET) methodologies has made it possible to study the in vivo brain metabolic correlates of human cognitive and behavioral functions. Moreover, as PET scan examinations can be repeated, the progression of the neuropathological process and its relation to cognitive dysfunction can be followed over time. In an effort to understand the changes in neural function that precede and accompany onset of dementia and their relation to clinical manifestations, in the last several years, we have conducted clinical, neuropsychological and brain metabolic studies in groups of Alzheimer’s disease patients at different stages of dementia severity or with distinct clinical pictures and in populations at risk for developing the disease. Here, we discuss the main findings and implications obtained from these studies.
date: 2000
date_type: published
publication: International Journal of Psychophysiology
volume: 37
number: 1
publisher: Elsevier
pagerange: 87-98
id_number: doi:10.1016/S0167-8760(00)00097-0
refereed: TRUE
issn: 0167-8760
official_url: http://doi.org/10.1016/S0167-8760(00)00097-0
citation:   Pietrini, Pietro and Alexander, Gene E. and Furey, Maura L. and Hampel, Harald and Guazzelli, Mario  The neurometabolic landscape of cognitive decline: in vivo studies with positron emission tomography in Alzheimer’s disease.  International Journal of Psychophysiology, 37 (1).  pp. 87-98.  ISSN 0167-8760      (2000)