TY  - JOUR
IS  - 8
PB  - Wolters Kluver
VL  - 8
Y1  - 1997///
UR  - http://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=1997&issue=05260&article=00009&type=abstract
JF  - Neuroreport
A1  - Alexander, Gene E.
A1  - Saunders, Ann M.
A1  - Szczepanik, Joanna
A1  - Strassburger, Terri L.
A1  - Pietrini, Pietro
A1  - Dani, Alessio
A1  - Furey, Maura L.
A1  - Mentis, Marc J.
A1  - Roses, Allen D.
A1  - Rapoport, Stanley I.
A1  - Schapiro, Mark B.
N2  - TO test the cognitive effects of aging and apolipoprotein E (APOE) in individuals at high risk for Alzheimer's disease (AD), we assessed APOE genotypes and performance on a battery of neuropsychological tests in 41 non-demented, Down syndrome (DS) adults. Old DS subjects (ages 41?61 years) showed poorer memory and orientation scores than young DS adults (ages 22?38 years), but the groups did not differ in other measures after we controlled for intellectual function. Language ability was inversely related to APOE genotype, even after age was controlled for, with the presence of the ϵ2 allele corresponding to better language skills than ϵ4. Age-related cognitive changes in non-demented DS adults are consistent with the early effects of AD. The relationship between basic linguistic skills and APOE genotype supports this genetic factor in influencing the development of dementia and AD neuropathology in DS.
SP  - 1835
TI  - Relation of age and apolipoprotein E to cognitive function in Down syndrome adults
EP  - 1840
ID  - eprints3422
SN  - 0959-4965
AV  - none
ER  -