eprintid: 3422
rev_number: 7
eprint_status: archive
userid: 69
dir: disk0/00/00/34/22
datestamp: 2016-04-12 09:23:24
lastmod: 2016-04-12 09:23:24
status_changed: 2016-04-12 09:23:24
type: article
metadata_visibility: show
creators_name: Alexander, Gene E.
creators_name: Saunders, Ann M.
creators_name: Szczepanik, Joanna
creators_name: Strassburger, Terri L.
creators_name: Pietrini, Pietro
creators_name: Dani, Alessio
creators_name: Furey, Maura L.
creators_name: Mentis, Marc J.
creators_name: Roses, Allen D.
creators_name: Rapoport, Stanley I.
creators_name: Schapiro, Mark B.
creators_id: 
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creators_id: pietro.pietrini@imtlucca.it
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title: Relation of age and apolipoprotein E to cognitive function in Down syndrome adults
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: TO test the cognitive effects of aging and apolipoprotein E (APOE) in individuals at high risk for Alzheimer's disease (AD), we assessed APOE genotypes and performance on a battery of neuropsychological tests in 41 non-demented, Down syndrome (DS) adults. Old DS subjects (ages 41–61 years) showed poorer memory and orientation scores than young DS adults (ages 22–38 years), but the groups did not differ in other measures after we controlled for intellectual function. Language ability was inversely related to APOE genotype, even after age was controlled for, with the presence of the ϵ2 allele corresponding to better language skills than ϵ4. Age-related cognitive changes in non-demented DS adults are consistent with the early effects of AD. The relationship between basic linguistic skills and APOE genotype supports this genetic factor in influencing the development of dementia and AD neuropathology in DS.
date: 1997
date_type: published
publication: Neuroreport
volume: 8
number: 8
publisher: Wolters Kluver
pagerange: 1835-1840
refereed: TRUE
issn: 0959-4965
official_url: http://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=1997&issue=05260&article=00009&type=abstract
citation:   Alexander, Gene E. and Saunders, Ann M. and Szczepanik, Joanna and Strassburger, Terri L. and Pietrini, Pietro and Dani, Alessio and Furey, Maura L. and Mentis, Marc J. and Roses, Allen D. and Rapoport, Stanley I. and Schapiro, Mark B.  Relation of age and apolipoprotein E to cognitive function in Down syndrome adults.  Neuroreport, 8 (8).  pp. 1835-1840.  ISSN 0959-4965      (1997)