eprintid: 3439
rev_number: 6
eprint_status: archive
userid: 6
dir: disk0/00/00/34/39
datestamp: 2016-04-13 09:06:19
lastmod: 2016-04-13 09:06:19
status_changed: 2016-04-13 09:06:19
type: article
metadata_visibility: show
creators_name: Pietrini, Pietro
creators_name: Furey, Maura L.
creators_name: Alexander, Gene E.
creators_name: Mentis, Marc J.
creators_name: Dani, Alessio
creators_name: Guazzelli, Mario
creators_name: Rapoport, Stanley I.
creators_name: Schapiro, Mark B.
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
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creators_id: 
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title: Association between brain functional failure and dementia severity in Alzheimer’s disease: resting versus stimulation PET study
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
abstract: OBJECTIVE: This study tested the hypothesis that regional cerebral glucose metabolism during neuronal activation is a more sensitive index of neuronal dysfunction and clinical severity in Alzheimer’s disease than is glucose metabolism at rest. METHOD: The subjects were 15 Alzheimer’s disease patients with a wide range of Mattis Dementia Rating Scale scores (23–128). By using positron emission tomography, absolute glucose metabolism was measured in the parietal, occipital (visual areas), and temporal (auditory areas) cortical regions during rest (eyes/ears covered) and audiovisual stimulation. RESULTS: In the parietal cortex, glucose metabolism correlated with dementia severity in both conditions. In contrast, in the relatively preserved visual and auditory cortical regions, glucose metabolism predicted dementia severity during stimulation but not at rest. CONCLUSIONS: These findings suggest that regional cerebral glucose metabolism during stimulation is a more sensitive index of the functional/metabolic failure of neuronal systems than is metabolism at rest
date: 1999-03
date_type: published
publication: American Journal of Psychiatry
volume: 56
number: 3
publisher: American Psychiatric publishing
pagerange: 470-473
refereed: TRUE
issn: 0002-953X
official_url: http://ajp.psychiatryonline.org/doi/abs/10.1176/ajp.156.3.470
citation:   Pietrini, Pietro and Furey, Maura L. and Alexander, Gene E. and Mentis, Marc J. and Dani, Alessio and Guazzelli, Mario and Rapoport, Stanley I. and Schapiro, Mark B.  Association between brain functional failure and dementia severity in Alzheimer’s disease: resting versus stimulation PET study.  American Journal of Psychiatry, 56 (3).  pp. 470-473.  ISSN 0002-953X      (1999)