TY  - JOUR
VL  - 2016
ID  - eprints3586
A1  - Cristallini, Caterina
A1  - Cibrario Rocchietti, Elisa
A1  - Gagliardi, Mariacristina
A1  - Mortati, Leonardo
A1  - Saviozzi, Silvia
A1  - Bellotti, Elena
A1  - Turinetto, Valentina
A1  - Sassi, Maria Paola
A1  - Barbani, Niccoletta
A1  - Giachino, Claudia
PB  - Hindawi Publishing Corporation
SN  - 1687-966X
N2  - The biomaterial scaffold plays a key role in most tissue engineering strategies. Its surface properties, micropatterning, degradation, and mechanical features affect not only the generation of the tissue construct in vitro, but also its in vivo functionality. The area of myocardial tissue engineering still faces significant difficulties and challenges in the design of bioactive scaffolds, which allow composition variation to accommodate divergence in the evolving myocardial structure. Here we aimed at verifying if a microstructured bioartificial scaffold alone can provoke an effect on stem cell behavior. To this purpose, we fabricated microstructured bioartificial polymeric constructs made of PLGA/gelatin mimicking anisotropic structure and mechanical properties of the myocardium. We found that PLGA/gelatin scaffolds promoted adhesion, elongation, ordered disposition, and early myocardial commitment of human mesenchymal stem cells suggesting that these constructs are able to crosstalk with stem cells in a precise and controlled manner. At the same time, the biomaterial degradation kinetics renders the PLGA/gelatin constructs very attractive for myocardial regeneration approaches.
TI  - Micro- and Macrostructured PLGA/Gelatin Scaffolds Promote Early Cardiogenic Commitment of Human Mesenchymal Stem Cells In Vitro
AV  - public
Y1  - 2016///
UR  - https://www.hindawi.com/journals/sci/2016/7176154/
JF  - Stem Cells International
ER  -