eprintid: 3586
rev_number: 11
eprint_status: archive
userid: 73
dir: disk0/00/00/35/86
datestamp: 2016-10-24 12:26:12
lastmod: 2016-10-24 12:26:12
status_changed: 2016-10-24 12:26:12
type: article
metadata_visibility: show
creators_name: Cristallini, Caterina
creators_name: Cibrario Rocchietti, Elisa
creators_name: Gagliardi, Mariacristina
creators_name: Mortati, Leonardo
creators_name: Saviozzi, Silvia
creators_name: Bellotti, Elena
creators_name: Turinetto, Valentina
creators_name: Sassi, Maria Paola
creators_name: Barbani, Niccoletta
creators_name: Giachino, Claudia
creators_id: 
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creators_id: mariacristina.gagliardi@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
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title: Micro- and Macrostructured PLGA/Gelatin Scaffolds Promote Early Cardiogenic Commitment of Human Mesenchymal Stem Cells In Vitro
ispublished: pub
subjects: QD
subjects: R1
divisions: CSA
full_text_status: public
abstract: The biomaterial scaffold plays a key role in most tissue engineering strategies. Its surface properties, micropatterning, degradation, and mechanical features affect not only the generation of the tissue construct in vitro, but also its in vivo functionality. The area of myocardial tissue engineering still faces significant difficulties and challenges in the design of bioactive scaffolds, which allow composition variation to accommodate divergence in the evolving myocardial structure. Here we aimed at verifying if a microstructured bioartificial scaffold alone can provoke an effect on stem cell behavior. To this purpose, we fabricated microstructured bioartificial polymeric constructs made of PLGA/gelatin mimicking anisotropic structure and mechanical properties of the myocardium. We found that PLGA/gelatin scaffolds promoted adhesion, elongation, ordered disposition, and early myocardial commitment of human mesenchymal stem cells suggesting that these constructs are able to crosstalk with stem cells in a precise and controlled manner. At the same time, the biomaterial degradation kinetics renders the PLGA/gelatin constructs very attractive for myocardial regeneration approaches.
date: 2016
date_type: published
publication: Stem Cells International
volume: 2016
publisher: Hindawi Publishing Corporation
pagerange: 7176154
id_number: 10.1155/2016/7176154
refereed: TRUE
issn: 1687-966X
official_url: https://www.hindawi.com/journals/sci/2016/7176154/
citation:   Cristallini, Caterina and Cibrario Rocchietti, Elisa and Gagliardi, Mariacristina and Mortati, Leonardo and Saviozzi, Silvia and Bellotti, Elena and Turinetto, Valentina and Sassi, Maria Paola and Barbani, Niccoletta and Giachino, Claudia  Micro- and Macrostructured PLGA/Gelatin Scaffolds Promote Early Cardiogenic Commitment of Human Mesenchymal Stem Cells In Vitro.  Stem Cells International, 2016.  p. 7176154.  ISSN 1687-966X      (2016)  
document_url: http://eprints.imtlucca.it/3586/1/7176154.pdf