relation: http://eprints.imtlucca.it/3603/
title: (Review article) Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression: meta-analysis
creator: Cristea, Ioana A.
creator: Gentili, Claudio
creator: Pietrini, Pietro
creator: Cuijpers, Pim
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: Background:Sponsorship bias has never been investigated for non-pharmacological treatments like psychotherapy.AimsWe examined industry funding and author financial conflict of interest (COI) in randomised controlled trials directly comparing psychotherapy and pharmacotherapy in depression.Method: We conducted a meta-analysis with subgroup comparisons for industry v. non-industry-funded trials, and respectively for trial reports with author financial COI v. those without.Results: In total, 45 studies were included. In most analyses, pharmacotherapy consistently showed significant effectiveness over psychotherapy, g = -0.11 (95% CI -0.21 to -0.02) in industry-funded trials. Differences between industry and non-industry-funded trials were significant, a result only partly confirmed in sensitivity analyses. We identified five instances where authors of the original article had not reported financial COI.ConclusionsIndustry-funded trials for depression appear to subtly favour pharmacotherapy over psychotherapy. Disclosure of all financial ties with the pharmaceutical industry should be encouraged.
publisher: The Royal College of Psychiatrists
date: 2016
type: Article
type: PeerReviewed
identifier:   Cristea, Ioana A. and Gentili, Claudio and Pietrini, Pietro and Cuijpers, Pim  (Review article) Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression: meta-analysis.  The British Journal of Psychiatry.   ISSN 0007-1250      (2016)  
relation: http://bjp.rcpsych.org/content/early/2016/10/20/bjp.bp.115.179275
relation: 10.1192/bjp.bp.115.179275