eprintid: 3603
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/36/03
datestamp: 2016-11-28 17:08:03
lastmod: 2016-11-28 17:08:03
status_changed: 2016-11-28 17:08:03
type: article
metadata_visibility: show
creators_name: Cristea, Ioana A.
creators_name: Gentili, Claudio
creators_name: Pietrini, Pietro
creators_name: Cuijpers, Pim
creators_id: 
creators_id: 
creators_id: pietro.pietrini@imtlucca.it
creators_id: 
title: (Review article) Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression: meta-analysis
ispublished: pub
subjects: RC0321
divisions: CSA
full_text_status: none
note: PMID: 27810891
abstract: Background:Sponsorship bias has never been investigated for non-pharmacological treatments like psychotherapy.AimsWe examined industry funding and author financial conflict of interest (COI) in randomised controlled trials directly comparing psychotherapy and pharmacotherapy in depression.Method: We conducted a meta-analysis with subgroup comparisons for industry v. non-industry-funded trials, and respectively for trial reports with author financial COI v. those without.Results: In total, 45 studies were included. In most analyses, pharmacotherapy consistently showed significant effectiveness over psychotherapy, g = -0.11 (95% CI -0.21 to -0.02) in industry-funded trials. Differences between industry and non-industry-funded trials were significant, a result only partly confirmed in sensitivity analyses. We identified five instances where authors of the original article had not reported financial COI.ConclusionsIndustry-funded trials for depression appear to subtly favour pharmacotherapy over psychotherapy. Disclosure of all financial ties with the pharmaceutical industry should be encouraged.
date: 2016
date_type: published
publication: The British Journal of Psychiatry
publisher: The Royal College of Psychiatrists
id_number: 10.1192/bjp.bp.115.179275
refereed: TRUE
issn: 0007-1250
official_url: http://bjp.rcpsych.org/content/early/2016/10/20/bjp.bp.115.179275
citation:   Cristea, Ioana A. and Gentili, Claudio and Pietrini, Pietro and Cuijpers, Pim  (Review article) Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression: meta-analysis.  The British Journal of Psychiatry.   ISSN 0007-1250      (2016)