@article{eprints3618,
            year = {2017},
          author = {L. Maffei and E. Picano and M. G. Andreassi and A. Angelucci and F. Baldacci and L. Baroncelli and T. Begenisic and P.F. Bellinvia and N. Berardi and L. Biagi and J. Bonaccorsi and E. Bonanni and U. Bonuccelli and Andrea Borghini and C, Braschi and M. Broccardi and R.M. Bruno and M. Caleo and C. Carlesi and L. Carnicelli and G. Cartoni and Luca Cecchetti and M.C. Cenni and R. Ceravolo and L. Chico and S. Cintoli and G. Cioni and M. Coscia and M. Costa and G. D?Angelo and P. D?Ascanio and M. De Nes and S. Del Turco and E. Di Coscio and M. Di Galante and N. Di Lascio and F. Faita and I. Falorni and U. Faraguna and A. Fenu and L. Fortunato and R. Franco and L. Gargani and R. Gargiulo and L. Ghiadoni and F. S. Giorgi and R. Iannarella and C. Iofrida and C. Kusmic and F. Limongi and M. Maestri and M. Maffei and S. Maggi and M. Mainardi and L. Mammana and A. Marabotti and V. Mariotti and E. Melissari and A. Mercuri and S. Micera and S. Molinaro and R. Narducci and T. Navarra and M. Noale and C. Pagni and S. Palumbo and R. Pasquariello and S. Pellegrini and Pietro Pietrini and T. Pizzorusso and A. Poli and L. Pratali and A. Retico and E. Ricciardi and G. Rota and A. Sale and S. Sbrana and G. Scabia and M. Scali and D. Scelfo and R. Sicari and G. Siciliano and F. Stea and S. Taddei and G. Tognoni and A. Tonacci and M. Tosetti and S. Turchi and L. Volpi},
         journal = {Scientific Reports},
           title = {Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study},
           pages = {39471},
          volume = {7},
       publisher = {Nature Publishing Group},
        keywords = {Dementia; Neurological Disorders},
        abstract = {Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65?89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.},
             url = {http://eprints.imtlucca.it/3618/}
}