%0 Journal Article
%@ 2045-2322
%A Maffei, L.
%A Picano, E.
%A Andreassi, M. G.
%A Angelucci, A.
%A Baldacci, F.
%A Baroncelli, L.
%A Begenisic, T.
%A Bellinvia, P.F.
%A Berardi, N.
%A Biagi, L.
%A Bonaccorsi, J.
%A Bonanni, E.
%A Bonuccelli, U.
%A Borghini, Andrea
%A Braschi, C,
%A Broccardi, M.
%A Bruno, R.M.
%A Caleo, M.
%A Carlesi, C.
%A Carnicelli, L.
%A Cartoni, G.
%A Cecchetti, Luca
%A Cenni, M.C.
%A Ceravolo, R.
%A Chico, L.
%A Cintoli, S.
%A Cioni, G.
%A Coscia, M.
%A Costa, M.
%A D’Angelo, G.
%A D’Ascanio, P.
%A De Nes, M.
%A Del Turco, S.
%A Di Coscio, E.
%A Di Galante, M.
%A Di Lascio, N.
%A Faita, F.
%A Falorni, I.
%A Faraguna, U.
%A Fenu, A.
%A Fortunato, L.
%A Franco, R.
%A Gargani, L.
%A Gargiulo, R.
%A Ghiadoni, L.
%A Giorgi, F. S.
%A Iannarella, R.
%A Iofrida, C.
%A Kusmic, C.
%A Limongi, F.
%A Maestri, M.
%A Maffei, M.
%A Maggi, S.
%A Mainardi, M.
%A Mammana, L.
%A Marabotti, A.
%A Mariotti, V.
%A Melissari, E.
%A Mercuri, A.
%A Micera, S.
%A Molinaro, S.
%A Narducci, R.
%A Navarra, T.
%A Noale, M.
%A Pagni, C.
%A Palumbo, S.
%A Pasquariello, R.
%A Pellegrini, S.
%A Pietrini, Pietro
%A Pizzorusso, T.
%A Poli, A.
%A Pratali, L.
%A Retico, A.
%A Ricciardi, E.
%A Rota, G.
%A Sale, A.
%A Sbrana, S.
%A Scabia, G.
%A Scali, M.
%A Scelfo, D.
%A Sicari, R.
%A Siciliano, G.
%A Stea, F.
%A Taddei, S.
%A Tognoni, G.
%A Tonacci, A.
%A Tosetti, M.
%A Turchi, S.
%A Volpi, L.
%D 2017
%F eprints:3618
%I Nature Publishing Group
%J Scientific Reports
%K Dementia; Neurological Disorders
%P 39471
%T Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study
%U http://eprints.imtlucca.it/3618/
%V 7
%X Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65–89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.