<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study"^^ . "Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65–89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects."^^ . "2017" . . . "7" . . "Nature Publishing Group"^^ . . . "Scientific Reports"^^ . . . "20452322" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "M."^^ . "Maffei"^^ . "M. Maffei"^^ . . "L."^^ . "Fortunato"^^ . "L. Fortunato"^^ . . "T."^^ . "Begenisic"^^ . "T. Begenisic"^^ . . "V."^^ . "Mariotti"^^ . "V. Mariotti"^^ . . "S."^^ . "Pellegrini"^^ . "S. Pellegrini"^^ . . "G."^^ . "Rota"^^ . "G. Rota"^^ . . "A."^^ . "Retico"^^ . "A. Retico"^^ . . "M."^^ . "Noale"^^ . "M. Noale"^^ . . "A."^^ . "Poli"^^ . "A. Poli"^^ . . "N."^^ . 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Ricciardi"^^ . . "P.F."^^ . "Bellinvia"^^ . "P.F. Bellinvia"^^ . . "L."^^ . "Mammana"^^ . "L. Mammana"^^ . . "L."^^ . "Chico"^^ . "L. Chico"^^ . . "Luca"^^ . "Cecchetti"^^ . "Luca Cecchetti"^^ . . "M."^^ . "Caleo"^^ . "M. Caleo"^^ . . "G."^^ . "D’Angelo"^^ . "G. D’Angelo"^^ . . "M."^^ . "Coscia"^^ . "M. Coscia"^^ . . "S."^^ . "Turchi"^^ . "S. Turchi"^^ . . "R."^^ . "Franco"^^ . "R. Franco"^^ . . "M.C."^^ . "Cenni"^^ . "M.C. Cenni"^^ . . . . . . "Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)"^^ . . . . . . "srep39471.pdf"^^ . . . "Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (Other)"^^ . . . . . . "preview.jpg"^^ . . . 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