…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study
type: AcademicArticle
type: Article
abstract: Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65–89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.
date: 2017
volume: 7
is part of: Scientific Reports
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
has version: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
has published: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
has document: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (Other)
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
type: Document
license: http://creativecommons.org/licenses/by-nc/3.0/
has file: srep39471.pdf
has part: srep39471.pdf

Nature Publishing Group
type: Organization

Scientific Reports
type: Collection
issn: 20452322

S. Sbrana
type: Person
given name: S.
family name: Sbrana

M. Tosetti
type: Person
given name: M.
family name: Tosetti

L. Chico
type: Person
given name: L.
family name: Chico

F. Faita
type: Person
given name: F.
family name: Faita

L. Fortunato
type: Person
given name: L.
family name: Fortunato

N. Di Lascio
type: Person
given name: N.
family name: Di Lascio

M.C. Cenni
type: Person
given name: M.C.
family name: Cenni

T. Pizzorusso
type: Person
given name: T.
family name: Pizzorusso

L. Volpi
type: Person
given name: L.
family name: Volpi

C, Braschi
type: Person
given name: C,
family name: Braschi

A. Mercuri
type: Person
given name: A.
family name: Mercuri

S. Micera
type: Person
given name: S.
family name: Micera

M. Coscia
type: Person
given name: M.
family name: Coscia

E. Picano
type: Person
given name: E.
family name: Picano

S. Taddei
type: Person
given name: S.
family name: Taddei

S. Cintoli
type: Person
given name: S.
family name: Cintoli

G. Rota
type: Person
given name: G.
family name: Rota

M. Scali
type: Person
given name: M.
family name: Scali

E. Ricciardi
type: Person
given name: E.
family name: Ricciardi

R. Iannarella
type: Person
given name: R.
family name: Iannarella

S. Molinaro
type: Person
given name: S.
family name: Molinaro

L. Maffei
type: Person
given name: L.
family name: Maffei

G. Cioni
type: Person
given name: G.
family name: Cioni

Andrea Borghini
type: Person
given name: Andrea
family name: Borghini

C. Iofrida
type: Person
given name: C.
family name: Iofrida

V. Mariotti
type: Person
given name: V.
family name: Mariotti

C. Carlesi
type: Person
given name: C.
family name: Carlesi

L. Gargani
type: Person
given name: L.
family name: Gargani

L. Pratali
type: Person
given name: L.
family name: Pratali

F. Stea
type: Person
given name: F.
family name: Stea

S. Turchi
type: Person
given name: S.
family name: Turchi

A. Poli
type: Person
given name: A.
family name: Poli

N. Berardi
type: Person
given name: N.
family name: Berardi

S. Del Turco
type: Person
given name: S.
family name: Del Turco

A. Fenu
type: Person
given name: A.
family name: Fenu

E. Bonanni
type: Person
given name: E.
family name: Bonanni

Luca Cecchetti
type: Person
given name: Luca
family name: Cecchetti

R. Pasquariello
type: Person
given name: R.
family name: Pasquariello

M. Broccardi
type: Person
given name: M.
family name: Broccardi

R.M. Bruno
type: Person
given name: R.M.
family name: Bruno

I. Falorni
type: Person
given name: I.
family name: Falorni

T. Navarra
type: Person
given name: T.
family name: Navarra

M. Noale
type: Person
given name: M.
family name: Noale

L. Mammana
type: Person
given name: L.
family name: Mammana

S. Maggi
type: Person
given name: S.
family name: Maggi

M. G. Andreassi
type: Person
given name: M. G.
family name: Andreassi

M. Mainardi
type: Person
given name: M.
family name: Mainardi

M. Costa
type: Person
given name: M.
family name: Costa

L. Baroncelli
type: Person
given name: L.
family name: Baroncelli

M. De Nes
type: Person
given name: M.
family name: De Nes

F. S. Giorgi
type: Person
given name: F. S.
family name: Giorgi

J. Bonaccorsi
type: Person
given name: J.
family name: Bonaccorsi

G. Scabia
type: Person
given name: G.
family name: Scabia

L. Biagi
type: Person
given name: L.
family name: Biagi

E. Melissari
type: Person
given name: E.
family name: Melissari

M. Maffei
type: Person
given name: M.
family name: Maffei

A. Sale
type: Person
given name: A.
family name: Sale

T. Begenisic
type: Person
given name: T.
family name: Begenisic

U. Bonuccelli
type: Person
given name: U.
family name: Bonuccelli

A. Tonacci
type: Person
given name: A.
family name: Tonacci

A. Angelucci
type: Person
given name: A.
family name: Angelucci

F. Limongi
type: Person
given name: F.
family name: Limongi

Pietro Pietrini
type: Person
given name: Pietro
family name: Pietrini

G. Siciliano
type: Person
given name: G.
family name: Siciliano

L. Ghiadoni
type: Person
given name: L.
family name: Ghiadoni

E. Di Coscio
type: Person
given name: E.
family name: Di Coscio

F. Baldacci
type: Person
given name: F.
family name: Baldacci

G. D’Angelo
type: Person
given name: G.
family name: D’Angelo

R. Sicari
type: Person
given name: R.
family name: Sicari

S. Pellegrini
type: Person
given name: S.
family name: Pellegrini

U. Faraguna
type: Person
given name: U.
family name: Faraguna

M. Di Galante
type: Person
given name: M.
family name: Di Galante

R. Ceravolo
type: Person
given name: R.
family name: Ceravolo

G. Tognoni
type: Person
given name: G.
family name: Tognoni

A. Retico
type: Person
given name: A.
family name: Retico

C. Kusmic
type: Person
given name: C.
family name: Kusmic

R. Gargiulo
type: Person
given name: R.
family name: Gargiulo

R. Narducci
type: Person
given name: R.
family name: Narducci

C. Pagni
type: Person
given name: C.
family name: Pagni

M. Caleo
type: Person
given name: M.
family name: Caleo

S. Palumbo
type: Person
given name: S.
family name: Palumbo

L. Carnicelli
type: Person
given name: L.
family name: Carnicelli

M. Maestri
type: Person
given name: M.
family name: Maestri

R. Franco
type: Person
given name: R.
family name: Franco

P.F. Bellinvia
type: Person
given name: P.F.
family name: Bellinvia

A. Marabotti
type: Person
given name: A.
family name: Marabotti

D. Scelfo
type: Person
given name: D.
family name: Scelfo

P. D’Ascanio
type: Person
given name: P.
family name: D’Ascanio

G. Cartoni
type: Person
given name: G.
family name: Cartoni

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (Other)
type: Document
is version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
is volatile version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
islightbox thumbnail version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
has file: lightbox.jpg
has part: lightbox.jpg

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (Other)
type: Document
is version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
is volatile version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
ispreview thumbnail version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
has file: preview.jpg
has part: preview.jpg

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (Other)
type: Document
is version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
is volatile version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
ismedium thumbnail version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
has file: medium.jpg
has part: medium.jpg

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (Other)
type: Document
is version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
is volatile version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
issmall thumbnail version of: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study (PDF)
has file: small.jpg
has part: small.jpg

HTML Summary of #3618 Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study
format: text/html
primary topic: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
type: Concept