TY  - JOUR
VL  - 7
ID  - eprints3618
PB  - Nature Publishing Group
SN  - 2045-2322
A1  - Maffei, L.
A1  - Picano, E.
A1  - Andreassi, M. G.
A1  - Angelucci, A.
A1  - Baldacci, F.
A1  - Baroncelli, L.
A1  - Begenisic, T.
A1  - Bellinvia, P.F.
A1  - Berardi, N.
A1  - Biagi, L.
A1  - Bonaccorsi, J.
A1  - Bonanni, E.
A1  - Bonuccelli, U.
A1  - Borghini, Andrea
A1  - Braschi, C,
A1  - Broccardi, M.
A1  - Bruno, R.M.
A1  - Caleo, M.
A1  - Carlesi, C.
A1  - Carnicelli, L.
A1  - Cartoni, G.
A1  - Cecchetti, Luca
A1  - Cenni, M.C.
A1  - Ceravolo, R.
A1  - Chico, L.
A1  - Cintoli, S.
A1  - Cioni, G.
A1  - Coscia, M.
A1  - Costa, M.
A1  - D?Angelo, G.
A1  - D?Ascanio, P.
A1  - De Nes, M.
A1  - Del Turco, S.
A1  - Di Coscio, E.
A1  - Di Galante, M.
A1  - Di Lascio, N.
A1  - Faita, F.
A1  - Falorni, I.
A1  - Faraguna, U.
A1  - Fenu, A.
A1  - Fortunato, L.
A1  - Franco, R.
A1  - Gargani, L.
A1  - Gargiulo, R.
A1  - Ghiadoni, L.
A1  - Giorgi, F. S.
A1  - Iannarella, R.
A1  - Iofrida, C.
A1  - Kusmic, C.
A1  - Limongi, F.
A1  - Maestri, M.
A1  - Maffei, M.
A1  - Maggi, S.
A1  - Mainardi, M.
A1  - Mammana, L.
A1  - Marabotti, A.
A1  - Mariotti, V.
A1  - Melissari, E.
A1  - Mercuri, A.
A1  - Micera, S.
A1  - Molinaro, S.
A1  - Narducci, R.
A1  - Navarra, T.
A1  - Noale, M.
A1  - Pagni, C.
A1  - Palumbo, S.
A1  - Pasquariello, R.
A1  - Pellegrini, S.
A1  - Pietrini, Pietro
A1  - Pizzorusso, T.
A1  - Poli, A.
A1  - Pratali, L.
A1  - Retico, A.
A1  - Ricciardi, E.
A1  - Rota, G.
A1  - Sale, A.
A1  - Sbrana, S.
A1  - Scabia, G.
A1  - Scali, M.
A1  - Scelfo, D.
A1  - Sicari, R.
A1  - Siciliano, G.
A1  - Stea, F.
A1  - Taddei, S.
A1  - Tognoni, G.
A1  - Tonacci, A.
A1  - Tosetti, M.
A1  - Turchi, S.
A1  - Volpi, L.
N2  - Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65?89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.
Y1  - 2017///
KW  - Dementia; Neurological Disorders
AV  - public
TI  - Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study
JF  - Scientific Reports
UR  - http://doi.org/10.1038/srep39471
ER  -