%V 7
%I Nature Publishing Group
%T Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study
%P 39471
%J Scientific Reports
%R doi:10.1038/srep39471
%L eprints3618
%D 2017
%X Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65?89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.
%A L. Maffei
%A E. Picano
%A M. G. Andreassi
%A A. Angelucci
%A F. Baldacci
%A L. Baroncelli
%A T. Begenisic
%A P.F. Bellinvia
%A N. Berardi
%A L. Biagi
%A J. Bonaccorsi
%A E. Bonanni
%A U. Bonuccelli
%A Andrea Borghini
%A C, Braschi
%A M. Broccardi
%A R.M. Bruno
%A M. Caleo
%A C. Carlesi
%A L. Carnicelli
%A G. Cartoni
%A Luca Cecchetti
%A M.C. Cenni
%A R. Ceravolo
%A L. Chico
%A S. Cintoli
%A G. Cioni
%A M. Coscia
%A M. Costa
%A G. D?Angelo
%A P. D?Ascanio
%A M. De Nes
%A S. Del Turco
%A E. Di Coscio
%A M. Di Galante
%A N. Di Lascio
%A F. Faita
%A I. Falorni
%A U. Faraguna
%A A. Fenu
%A L. Fortunato
%A R. Franco
%A L. Gargani
%A R. Gargiulo
%A L. Ghiadoni
%A F. S. Giorgi
%A R. Iannarella
%A C. Iofrida
%A C. Kusmic
%A F. Limongi
%A M. Maestri
%A M. Maffei
%A S. Maggi
%A M. Mainardi
%A L. Mammana
%A A. Marabotti
%A V. Mariotti
%A E. Melissari
%A A. Mercuri
%A S. Micera
%A S. Molinaro
%A R. Narducci
%A T. Navarra
%A M. Noale
%A C. Pagni
%A S. Palumbo
%A R. Pasquariello
%A S. Pellegrini
%A Pietro Pietrini
%A T. Pizzorusso
%A A. Poli
%A L. Pratali
%A A. Retico
%A E. Ricciardi
%A G. Rota
%A A. Sale
%A S. Sbrana
%A G. Scabia
%A M. Scali
%A D. Scelfo
%A R. Sicari
%A G. Siciliano
%A F. Stea
%A S. Taddei
%A G. Tognoni
%A A. Tonacci
%A M. Tosetti
%A S. Turchi
%A L. Volpi
%K Dementia; Neurological Disorders