relation: http://eprints.imtlucca.it/3732/
title: Organization and hierarchy of the human functional brain network lead to a chain-like core
creator: Mastrandrea, Rossana
creator: Gabrielli, Andrea
creator: Piras, Fabrizio
creator: Spalletta, Gianfranco
creator: Caldarelli, Guido
creator: Gili, Tommaso
subject: HA Statistics
subject: QC Physics
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey matter regions) and to extract information out of the noise. Here we present the analysis of functional magnetic resonance imaging data from forty healthy humans at rest for the investigation of the basal scaffold of the functional brain network organization. We show how brain regions tend to coordinate by forming ahighly hierarchical chain-like structure of homogeneously clustered anatomical areas. A maximum spanning tree approach revealed the centrality of the occipital cortex and the peculiar aggregation of  cerebellar regions to form a closed core. We also report the hierarchy of network segregation and the level of clusters integration as a function of the connectivity strength between brain regions.
publisher: Nature Publishing Group
date: 2017-07-07
type: Article
type: PeerReviewed
format: application/pdf
language: en
rights: cc_by_nc_nd
identifier: http://eprints.imtlucca.it/3732/1/s41598-017-04716-3.pdf
identifier:   Mastrandrea, Rossana and Gabrielli, Andrea and Piras, Fabrizio and Spalletta, Gianfranco and Caldarelli, Guido and Gili, Tommaso  Organization and hierarchy of the human functional brain network lead to a chain-like core.  Scientific Reports, 7 (1).   ISSN 2045-2322      (2017)  
relation: http://doi.org/10.1038/s41598-017-04716-3
relation: doi:10.1038/s41598-017-04716-3