eprintid: 3732
rev_number: 20
eprint_status: archive
userid: 76
dir: disk0/00/00/37/32
datestamp: 2017-08-03 07:18:17
lastmod: 2017-08-03 07:18:17
status_changed: 2017-08-03 07:18:17
type: article
metadata_visibility: show
creators_name: Mastrandrea, Rossana
creators_name: Gabrielli, Andrea
creators_name: Piras, Fabrizio
creators_name: Spalletta, Gianfranco
creators_name: Caldarelli, Guido
creators_name: Gili, Tommaso
creators_id: rossana.mastrandrea@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: guido.caldarelli@imtlucca.it
creators_id: 
title: Organization and hierarchy of the human functional brain network lead to a chain-like core
ispublished: pub
subjects: HA
subjects: QC
subjects: RC0321
divisions: EIC
full_text_status: public
keywords: Complex networks; Network models
abstract: The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey matter regions) and to extract information out of the noise. Here we present the analysis of functional magnetic resonance imaging data from forty healthy humans at rest for the investigation of the basal scaffold of the functional brain network organization. We show how brain regions tend to coordinate by forming ahighly hierarchical chain-like structure of homogeneously clustered anatomical areas. A maximum spanning tree approach revealed the centrality of the occipital cortex and the peculiar aggregation of
cerebellar regions to form a closed core. We also report the hierarchy of network segregation and the level of clusters integration as a function of the connectivity strength between brain regions.
date: 2017-07-07
date_type: published
publication: Scientific Reports
volume: 7
number: 1
publisher: Nature Publishing Group
id_number: doi:10.1038/s41598-017-04716-3
refereed: TRUE
issn: 2045-2322
official_url: http://doi.org/10.1038/s41598-017-04716-3
citation:   Mastrandrea, Rossana and Gabrielli, Andrea and Piras, Fabrizio and Spalletta, Gianfranco and Caldarelli, Guido and Gili, Tommaso  Organization and hierarchy of the human functional brain network lead to a chain-like core.  Scientific Reports, 7 (1).   ISSN 2045-2322      (2017)  
document_url: http://eprints.imtlucca.it/3732/1/s41598-017-04716-3.pdf