relation: http://eprints.imtlucca.it/3747/
title: Memory and anatomical change in severe non missile traumatic brain injury: ∼1 vs. ∼8 years follow-up
creator: Tomaiuolo, Francesco
creator: Bivona, Umberto
creator: Lerch, Jason P.
creator: Paola, Margherita Di
creator: Carlesimo, Giovanni A.
creator: Ciurli, Paola
creator: Matteis, Mariella
creator: Cecchetti, Luca
creator: Forcina, Antonio
creator: Silvestro, Daniela
creator: Azicnuda, Eva
creator: Sabatini, Umberto
creator: Giacomo, Dina Di
creator: Caltagirone, Carlo
creator: Petrides, Michael
creator: Formisano, Rita
subject: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
description: In previous studies, we investigated a group of subjects who had suffered from a severe non missile traumatic brain injury (nmTBI) without macroscopic focal lesions and we found brain atrophy involving the hippocampus, fornix, corpus callosum, optic chiasm, and optic radiations. Memory test scores correlated mainly with fornix volumes 37,38. In the present study, we re-examined 11 of these nmTBI subjects approximately 8 yr later. High-spatial resolution \{T1\} weighted magnetic resonance images of the brain (1 mm3) and standardised memory tests were performed once more in order to compare brain morphology and memory performance originally assessed 3–13 months after head injury (first study) and after 8–10 yr (present study). An overall improvement of memory test performance was demonstrated in the latest assessment, indicating that cognitive recovery in severe nmTBI subjects had not been completed within 3–13 months post-injury. It is notable that the volumes of the fornix and the hippocampus were reduced significantly from normal controls, but these volumes do not differ appreciatively between nmTBI subjects at first (after ∼1 yr) and at second (after ∼8 yr) scans. On the contrary, a clear reduction in the volume of the corpus callosus can be observed after ∼1 yr and a further significant reduction is evident after ∼8 yr, indicating that the neural degeneration in severe nmTBI continues long after the head trauma and relates to specific structures and not to the overall brain.
publisher: Elsevier
date: 2012
type: Article
type: PeerReviewed
identifier:   Tomaiuolo, Francesco and Bivona, Umberto and Lerch, Jason P. and Paola, Margherita Di and Carlesimo, Giovanni A. and Ciurli, Paola and Matteis, Mariella and Cecchetti, Luca and Forcina, Antonio and Silvestro, Daniela and Azicnuda, Eva and Sabatini, Umberto and Giacomo, Dina Di and Caltagirone, Carlo and Petrides, Michael and Formisano, Rita  Memory and anatomical change in severe non missile traumatic brain injury: ∼1 vs. ∼8 years follow-up.  Brain Research Bulletin, 87 (4–5).  373 - 382.  ISSN 0361-9230      (2012)  
relation: http://www.sciencedirect.com/science/article/pii/S0361923012000093
relation: 10.1016/j.brainresbull.2012.01.008