TY  - JOUR
EP  -  382
ID  - eprints3747
N2  - In previous studies, we investigated a group of subjects who had suffered from a severe non missile traumatic brain injury (nmTBI) without macroscopic focal lesions and we found brain atrophy involving the hippocampus, fornix, corpus callosum, optic chiasm, and optic radiations. Memory test scores correlated mainly with fornix volumes 37,38. In the present study, we re-examined 11 of these nmTBI subjects approximately 8 yr later. High-spatial resolution \{T1\} weighted magnetic resonance images of the brain (1 mm3) and standardised memory tests were performed once more in order to compare brain morphology and memory performance originally assessed 3?13 months after head injury (first study) and after 8?10 yr (present study). An overall improvement of memory test performance was demonstrated in the latest assessment, indicating that cognitive recovery in severe nmTBI subjects had not been completed within 3?13 months post-injury. It is notable that the volumes of the fornix and the hippocampus were reduced significantly from normal controls, but these volumes do not differ appreciatively between nmTBI subjects at first (after ?1 yr) and at second (after ?8 yr) scans. On the contrary, a clear reduction in the volume of the corpus callosus can be observed after ?1 yr and a further significant reduction is evident after ?8 yr, indicating that the neural degeneration in severe nmTBI continues long after the head trauma and relates to specific structures and not to the overall brain.
SN  - 0361-9230
UR  - http://www.sciencedirect.com/science/article/pii/S0361923012000093
TI  - Memory and anatomical change in severe non missile traumatic brain injury: ?1 vs. ?8 years follow-up
AV  - none
KW  - Craniocerebral trauma; nmTBI; CHI; Coma; Neuroanatomy; Memory
VL  - 87
SP  - 373 
A1  - Tomaiuolo, Francesco
A1  - Bivona, Umberto
A1  - Lerch, Jason P.
A1  - Paola, Margherita Di
A1  - Carlesimo, Giovanni A.
A1  - Ciurli, Paola
A1  - Matteis, Mariella
A1  - Cecchetti, Luca
A1  - Forcina, Antonio
A1  - Silvestro, Daniela
A1  - Azicnuda, Eva
A1  - Sabatini, Umberto
A1  - Giacomo, Dina Di
A1  - Caltagirone, Carlo
A1  - Petrides, Michael
A1  - Formisano, Rita
PB  - Elsevier
IS  - 4?5
JF  - Brain Research Bulletin
Y1  - 2012///
ER  -